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Efficient red-to-NIR photo-uncaging and applications in therapy

Award Number: R15EB034477
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/08/2024
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Efficient red-to-NIR photo-uncaging and applications in therapy - PROJECT SUMMARY Many light-responsive systems have been produced via natural evolution, including opsins, and phytochromes, while chemists have added to the list of light-responsive molecules for new tools. Scientists have embraced the use of these light-responsive tools to construct new materials, and we’ve just scratched the surface of the potential in this important field, particularly in the direction of making efficient red-to-near-infrared (red-to-NIR) light-responsive groups. The promise of red-to-NIR light resides in deeper penetration depth, less scattering and absorption by the sample, and less photodamage. Though approaches that use two-photon and lanthanide nanoparticles exhibit promising progress in allowing red-to-NIR absorption, developing organic-based materials that work under low power LED light is still challenging and such materials would expand the toolboxes and facilitate addressing a number of urgent questions. The organic-based platforms will benefit the fundamental understanding of chemical structure-to-property relationships, as well as impact many intriguing emerging applications, such as precision drug delivery, neuron modulation, light-triggered reactions, and gene therapy activation. Because of the much lower photon energy in the red-to-NIR region compared with UV and blue light, efficient red-to-NIR responsive is still challenging. This proposal aims to develop novel boron-dipyrromethene (BODIPY) based photo-uncaging groups that build upon weak covalent N-O bond. In particular, the weak dissociation energy of N-O permits the cleavage after absorbing low energy red-to-NIR photon, which is ideal for biological and biomedical applications. By varying and modifying the chemical structures, we intend to increase photo-uncaging efficiency by rigidifying the structure and for the first time facilitate dual cargo release from BODIPY. After conjugating with a cancer targeting unit, biomedical applications of these novel photo-uncaging materials will be demonstrated in vitro and in vivo in light-triggered drug delivery. Overall, the capability of efficient photo-uncaging in the red-to-NIR window will support more advanced experimental designs, and the convergence of basic research with applications will contribute to expanding knowledge while benefiting undergraduate researchers for broad impact.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	7/28/2026	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $406,832 )
2024	2024	NEW JERSEY INSTITUTE OF TECHNOLOGY	323 DR MARTIN LUTHER KING JR BLVD	NEWARK	NJ	07102	ESSEX	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/7/2024	NEW	$406,832
														Subtotal = $406,832

Grand Total All Awards = $406,832

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Efficient red-to-NIR photo-uncaging and applications in therapy

Award Number: R15EB034477

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/08/2024

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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