Intestinal Microbial Communities and Metabolites Changes Associated with Long-term Stress Induced Inflammatory Bowel Disease - Intestinal Microbial Communities and Metabolites Changes Associated with Long-term Stress Induced Inflammatory Bowel Disease PROJECT SUMMARY/ABSTRACT The intestinal microbiome of a host plays an important role in the growth and development of the host. This research investigates the Gut-Brain-Microbiota Axis (GBMAx) and its role in the complex relationship between Inflammatory Bowel Disease (IBD) and stress. Recent studies emphasize the gut microbiome's influence on host behavior and immune system support. Disruptions in the gut microbiome can lead to stress-induced chronic diseases like IBD and Type 2 diabetes. However, the exact nature of these alterations and their impact on host health and recovery remains unclear. Therefore, the goal of our study is to determine the role of stress- induced altered GBMAx in the development of IBD. The hypothesis is that stressed voles' intestinal microbiome will exhibit a composition and metabolites associated with adverse health outcomes, making them more susceptible to IBD. The study aims to understand how prolonged social isolation and IBD induction affect the gut microbiome of prairie voles (PV). Preliminary findings indicate differences in microbial markers associated with stress and colitis. Unraveling these interactions could provide insights into potential interventions for individuals with IBD or facing physiological stress. This study will elucidate the interplay of chronic stress, altered exploration, and anxiety-relevant behaviors which lead to changes in the gut microbiome ultimately causing IBD. Additionally, it enhances our understanding of specific bacterial community members related to stress, anxiety, and chronic systemic diseases. The research will engage graduate and undergraduate students, providing them with valuable hands-on experience. The broader impact includes identifying microbial markers linked to better health, diet interventions, and insights into the effects of social isolation on mental, and digestive health.
