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Persistent Effects of Dietary Protein Restriction on Protein Motivation and Underlying Physiology

Award Number: R15DK139555
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary It is often assumed that animals rapidly adapt behaviorally and physiologically to nutritional challenges and that adaptations to such challenges carry implications for human health. Very little work has been conducted to directly test this assumption and our preliminary data indicate that dietary protein restriction exerts effects on protein motivation that continue once protein intake is normalized. The proposed project will assess the persistence of the effects of dietary protein restriction on two measures of protein motivation – preference and economic “demand” – and on the physiological correlates of protein motivation – FGF21 production and mesolimbic dopamine system activity in response to protein ingestion. The work proposed in this application will be the first to address the question of how animals adapt behaviorally and physiologically when dietary protein is normalized following a period of dietary protein restriction. This work will be significant because it will directly test the assumption, implicit in most work in the field, that animals dynamically respond to nutritional needs.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $455,398 )
2024	2024	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/5/2024	NEW	$455,398
														Subtotal = $455,398

Grand Total All Awards = $455,398

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Persistent Effects of Dietary Protein Restriction on Protein Motivation and Underlying Physiology

Award Number: R15DK139555

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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