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Integrating data from a wideband acoustic immittance database to develop machine-learning models that characterize pathology in auditory measurements

Award Number: R15DC014129
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/05/2014
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Integrating data from a wideband acoustic immittance database to develop machine-learning models that characterize pathology in auditory measurements - PROJECT SUMMARY / ABSTRACT This work provides fundamental knowledge for the development of wideband acoustic immittance (WAI) measures as a noninvasive auditory diagnostic tool, where WAI refers to the collection of measurements that include absorbance, power reflectance, impedance, and related quantities. Potential uses of these measures include (1) detection of fluid in newborn and young infant ears where tympanometry is less successful and early diagnosis can be critical to supporting normal speech and language development, (2) identification of the cause of a conductive hearing loss (e.g., fluid, disarticulated ossicle, fixed ossicle), and (3) monitoring changes in middle-ear stiffness that result from intracranial pressure changes. The proposed work continues to expand and update the world’s only online WAI database and corresponding website, which was developed during the first two cycles of this grant; the database now includes more than 4.9 million rows of WAI data from 9903 subjects and 41 publications that collectively include both normal and diseased ears from subjects of all ages. This database has provided and will continue to provide additional measurements that the hearing community can utilize to (1) define features of normative measures for clinical application of WAI measurements, (2) determine how specific pathologies affect WAI, and (3) train systems that apply machine learning for the interpretation of WAI measurements. The proposed work expands upon the work in previous grant cycles to include (1) controlled laboratory-based WAI measurements that will inform criteria for the development of WAI measurement validity criteria by systematically studying acoustic leaks and probe placements along the canal and (2) the development of machine-learning models to classify WAI measurements made on normal and abnormal ears and to ultimately classify specific types of pathologies. A second emphasis of the proposed work is the research-based education of undergraduate students at Smith College, an all-women’s liberal arts college. Undergraduate engineering, computer science, statistics, data science, and mathematics students will be actively involved in all areas of the proposed work, with the goal of encouraging them to continue their education at the graduate level where they can contribute to health-related research.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $423,986 )
2024	2024	THE TRUSTEES OF THE SMITH COLLEGE	10 ELM ST	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	7/8/2024	COMPETING CONTINUATION	$421,141
2024	2024	THE TRUSTEES OF THE SMITH COLLEGE	10 ELM ST	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	001	3	8/8/2024	COMPETING CONTINUATION	$2,845
														Subtotal = $423,986

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2019	THE TRUSTEES OF THE SMITH COLLEGE	10 ELM ST	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	2	5/10/2023	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = -$33 )
2020	2014	TRUSTEES OF THE SMITH COLLEGE, THE	1 CHAPIN WAY	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	1	10/1/2019	NEW	-$33
														Subtotal = -$33

Issue Date FY: 2019 ( Subtotal = $387,220 )
2019	2019	TRUSTEES OF THE SMITH COLLEGE, THE	1 CHAPIN WAY	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	2	6/19/2019	COMPETING CONTINUATION	$387,220
														Subtotal = $387,220

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2014	TRUSTEES OF THE SMITH COLLEGE, THE	1 CHAPIN WAY	NORTHAMPTON	MA	01063	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	1	4/10/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $334,817 )
2014	2014	SMITH COLLEGE	7 College Lane	NORTHAMPTON	MA	01060	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	1	6/3/2014	NEW	$334,817
														Subtotal = $334,817

Grand Total All Awards = $1,145,990

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Integrating data from a wideband acoustic immittance database to develop machine-learning models that characterize pathology in auditory measurements

Award Number: R15DC014129

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/05/2014

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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