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Role of Parabrachial Nucleus Neuropeptides in Feeding

Award Number: R15DC007389
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2005
PERIOD OF PERFORMANCE END DATE: 06/30/2016

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Role of Parabrachial Nucleus Neuropeptides in Feeding - DESCRIPTION (provided by applicant): Advances in obesity treatment may be provided by continued resolution of the neural circuits that mediate leptin, ghrelin, and insulin responses. Considerable recent research has detailed first and second order sites in hypothalamic regions that are sensitive to leptin, insulin, and ghrelin input. Forebrain neurons expressing neuropeptides throughout the brain are sensitive to these hormones and act as downstream mediators to influence feeding and metabolism. These neuropeptides, such as neuropeptide Y (NPY) and pro-opioimelanocortin products (MC), act or have receptors in forebrain and hindbrain locations. An important goal for future research is to determine how such neuropeptides function in brainstem nuclei and to determine how these nuclei interact with forebrain nuclei (e.g., hypothalamus) that are sensitive to leptin, ghrelin, and insulin. This proposal will continue to evaluate the effects of NPY and MC receptor ligands on feeding and electrophysiological taste and visceral responses in the pontine parabrachial nucleus (PBN), a brainstem nucleus that receives significantly overlapping taste and visceral afferent inputs, receives direct NPY and MC input from the hypothalamus, and sends output to brainstem nuclei controlling oral movement. The first experiments assess the effects of direct PBN microinjectons of NPY and MC receptor antagonists on feeding microstructure. The following experiments assess the effects of NPY and MC receptor antagonists on neural PBN gustatory and gastric distension responses when NPY and MC agonists are applied to brain ventricles or their antagonists are microinjected directly around PBN neurons. If direct PBN application of NPY or MC receptor ligands affect feeding, this should be observed at the neurophysiological level and will serve to better clarify the functional role(s) of hypothalamic neuropeptides in the brainstem. PUBLIC HEALTH RELEVANCE: Feeding and metabolic disorders such as obesity, anorexia, bulimia, failure to thrive, gastric reflux, cachexia, early satiety, delayed gastric emptying, dysgeusia, and anosmia contribute to diseases including hypertension, stroke, diabetes, and heart disease, and they account for many health-care costs. Elucidating the neural systems that control feeding is, therefore, a fundamental goal for clinical as well as basic science. This proposal will continue to explore the role of the brainstem as a site of feeding-related hypothalamic neuropeptide action and thus contribute to basic research that could help to identify potential pharmacological therapeutic targets.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2011	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	010025000	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	12/18/2015	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $0 )
2015	2011	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	7/22/2015	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2011	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	11/5/2013	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $0 )
2012	2008	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	2	9/3/2012	COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2011 ( Subtotal = $450,012 )
2011	2011	TRUSTEES OF AMHERST COLLEGE	P.O. BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	3	6/9/2011	COMPETING CONTINUATION	$450,012
														Subtotal = $450,012

Issue Date FY: 2010 ( Subtotal = $0 )
2010	2009	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Trans-NIH Recovery Act Research Support	000	2	5/7/2010	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2009 ( Subtotal = $141,310 )
2009	2009	TRUSTEES OF AMHERST COLLEGE	P.O. BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Trans-NIH Recovery Act Research Support	000	2	7/15/2009	SUPPLEMENT FOR EXPANSION	$79,857
2009	2009	TRUSTEES OF AMHERST COLLEGE	P.O. BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Trans-NIH Recovery Act Research Support	001	2	8/12/2009	SUPPLEMENT FOR EXPANSION	$61,453
														Subtotal = $141,310

Issue Date FY: 2008 ( Subtotal = $237,000 )
2008	2008	TRUSTEES OF AMHERST COLLEGE	POST OFFICE BOX 5000	AMHERST	MA	01002	HAMPSHIRE	USA	Research Related to Deafness and Communication Disorders	000	2	2/19/2008	COMPETING CONTINUATION	$237,000
														Subtotal = $237,000

Issue Date FY: 2005 ( Subtotal = $220,800 )
2005	2005	BOSTON COLLEGE	ST THOMAS MORE HALL, RM 270	CHESTNUT HILL	MA	02167		USA	Research Related to Deafness and Communication Disorders	000	1	3/30/2005	NEW	$220,800
														Subtotal = $220,800

Grand Total All Awards = $1,049,122

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Role of Parabrachial Nucleus Neuropeptides in Feeding

Award Number: R15DC007389

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2005

PERIOD OF PERFORMANCE END DATE: 06/30/2016

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