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Mindful MAT Adherence: Mindfulness-Based Relapse Prevention (MBRP) to improve extended-release naltrexone (XR-NTX) adherence and drug-use outcomes for opioid use disorder (OUD).

Award Number: R15DA050102
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/30/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Mindful MAT Adherence: Mindfulness-Based Relapse Prevention (MBRP) to improve extended-release naltrexone (XR-NTX) adherence and drug-use outcomes for opioid use disorder (OUD). - PROJECT SUMMARY/ABSTRACT This proposal aims to determine whether an adjunctive Mindfulness-Based Relapse Prevention (MBRP) treatment program improves medication adherence and reduces drug-use among opioid use disorder (OUD) patients receiving extended-release naltrexone (XR-NTX). The broad long-term objectives of this project are to investigate how integrative pharmacological and behavioral treatments improve OUD treatment outcomes. XR-NTX is an evidenced based medication-assisted treatment (MAT) for OUD that has demonstrated utility in reducing opioid craving and rates of relapse and overdose deaths. However, a large portion of OUD patients demonstrate poor adherence to this medication and subsequently face increased vulnerability to future drug- use. Limited research has examined how behavioral treatments can increase MAT adherence. Mindfulness (i.e., present-centered nonjudgmental awareness), associates with self-care and addiction severity among with substance use disorders (SUD). MBRP is an evidenced-based behavioral group intervention that has demonstrated efficacy in reducing drug-use among patients in recovery from SUD. Emerging research suggests that combining MBRP into MAT for OUD may improve medication adherence and reduce drug-use. The primary study aim is to determine whether MBRP, compared to treatment-as-usual (TAU), delivered to OUD patients receiving XR-NTX through enrollment in a residential addiction treatment facility, results in improved MAT adherence and reduced drug-use following residential discharge. As MBRP is understood to improve self-care and mental health via increases in mindfulness and distress tolerance, the second study aim will test whether these mechanisms of change mediate XR-NTX adherence and drug-use outcomes. As prior trauma exposure is observed to undermine treatment efforts for SUDs a third exploratory study aim will determine the extent to which baseline trauma exposure and posttraumatic stress undermine XR-NTX adherence and drug-use. Expected outcomes are that MBRP participants will demonstrate (1) increased XR- NTX adherence and reduced drug-use monitored across three-months post-treatment, (2) that increased mindfulness and distress tolerance will mediate these outcomes, and (3) that prior trauma exposure and posttraumatic stress will moderate outcomes for TAU participants, but not for MBRP participants. Executing this project will provide enriching research opportunities for student research assistants. Providing students with systematic training and opportunities for exposure to research activities is fundamental to the study PI’s career aspirations and is an essential component to the successful execution of this research proposal. Findings from this research proposal will contribute to endeavor to improve addiction treatment efforts, will provide substantive opportunities for student researchers, and will provide foundational support for the PI’s pursuit of additional R01 funding prior to the conclusion of this study.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$6,470 )
2025	2020	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	201 CARTER DR STE 200	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	000	1	12/24/2024	NEW	-$6,470
														Subtotal = -$6,470

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	700 S HIGH ST	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	001	1	8/14/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2020	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	700 S HIGH ST	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	000	1	8/14/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $131,167 )
2021	2021	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	700 S HIGH ST	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	001	1	9/16/2021	SUPPLEMENT FOR EXPANSION	$131,167
2021	2020	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	700 S HIGH ST	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	000	1	6/2/2021	NEW	$0
														Subtotal = $131,167

Issue Date FY: 2020 ( Subtotal = $417,000 )
2020	2020	WEST CHESTER UNIVERSITY OF PENNSYLVANIA	700 S HIGH ST	WEST CHESTER	PA	19383	CHESTER	USA	Drug Use and Addiction Research Programs	000	1	9/24/2020	NEW	$417,000
														Subtotal = $417,000

Grand Total All Awards = $541,697

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Mindful MAT Adherence: Mindfulness-Based Relapse Prevention (MBRP) to improve extended-release naltrexone (XR-NTX) adherence and drug-use outcomes for opioid use disorder (OUD).

Award Number: R15DA050102

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/30/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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