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Effects of Chronic Stress on Relapse: Role of Dopamine D1-Like Receptors

Award Number: R15DA035432
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2014
PERIOD OF PERFORMANCE END DATE: 04/30/2022

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Effects of Chronic Stress on Relapse: Role of Dopamine D1-Like Receptors - PROJECT SUMMARY Drug addiction is a chronic disorder characterized by high rates of relapse, even after long periods of abstinence from drug use. Similarly, long-term success of dietary treatments is low because most individuals relapse to unhealthy eating habits within months of starting treatment. Therefore, investigations into the environmental factors and neural mechanisms that increase one's vulnerability to relapse are critical to the development of novel treatment strategies for these major public health problems. Although chronic stress has long been associated with relapse vulnerability in the clinical literature, relatively few pre-clinical studies have used models of relapse that incorporate a chronic stressor. During the current funding period, we added a chronic stress component to two widely used animal models of craving and relapse: the extinction/reinstatement model and the related forced abstinence model. We showed that animals with a history of chronic stress displayed greater relapse to drug and food seeking compared to unstressed rats for up to 1 week following the termination of stress. We also demonstrated that systemic dopamine D1-like receptor antagonism during chronic stress attenuated the effects of the stress on subsequent relapse-like behavior. Building on these findings, Aim 1 will determine the effects of chronic stress on relapse to cocaine and palatable food seeking following punishment-induced (self-imposed) abstinence. This model captures the human situation in which abstinence is self-imposed due to the negative consequences of continued seeking or use, and therefore, may have a translational advantage. Aim 2 will determine the anatomical location of chronic stress' dopaminergic mechanism by targeting discrete regions of medial prefrontal cortex with the selective D1-like receptor antagonist SCH-39166. Along with identifying the environmental and neuropharmacological determinants of relapse to cocaine and palatable food seeking as a means to inform novel treatment strategies, these studies will provide undergraduate students with meaningful, hands-on research experiences, thereby enhancing the research environment at Bloomsburg University.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$1 )
2020	2019	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 E 2ND ST	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	000	2	10/1/2019	COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2019 ( Subtotal = $371,244 )
2019	2019	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 E 2ND ST	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	002	2	6/13/2019	COMPETING CONTINUATION	$1
2019	2019	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 E 2ND ST	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	000	2	4/25/2019	COMPETING CONTINUATION	$371,244
2019	2014	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 E 2ND ST	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	001	1	6/13/2019	NEW	-$1
														Subtotal = $371,244

Issue Date FY: 2017 ( Subtotal = $0 )
2017	2014	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 E 2ND ST	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	000	1	6/9/2017	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $263,271 )
2014	2014	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 EAST SECOND STREET	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	001	1	7/18/2014	NEW	$0
2014	2014	BLOOMSBURG UNIVERSITY OF PENNSYLVANIA	400 EAST SECOND STREET	BLOOMSBURG	PA	17815	COLUMBIA	USA	Drug Use and Addiction Research Programs	000	1	7/14/2014	NEW	$263,271
														Subtotal = $263,271

Grand Total All Awards = $634,514

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Effects of Chronic Stress on Relapse: Role of Dopamine D1-Like Receptors

Award Number: R15DA035432

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2014

PERIOD OF PERFORMANCE END DATE: 04/30/2022

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