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Effects of age and lesion location on motor, behavioral and cognitive outcomes in pediatric posterior fossa tumors

Award Number: R15CA271450
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2026

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Effects of age and lesion location on motor, behavioral and cognitive outcomes in pediatric posterior fossa tumors - PROJECT SUMMARY Sixty percent of childhood brain tumors are located in the posterior fossa, which includes the cerebellum. Children with developmental cerebellar damage are at an increased risk for a range of adverse outcomes, including higher rates of autism diagnoses and long term cognitive and academic challenges. Traditionally considered a motor structure, extensive evidence now links the cerebellum to various cognitive and behavioral functions, and atypical cerebellar structure and function has been reported in multiple neurodevelopmental and psychiatric disorders. A key feature of cerebellar neuroanatomy is the existence of functional subregions that support sensorimotor and multiple non-motor functions. This leads to the hypothesis that motor, cognitive, and behavioral outcomes should be predictable based on lesion location. While our previous lesion-symptom mapping studies have shown this to be the case in adult cerebellar stroke patients, there are limited studies linking location of lesion to outcomes in pediatric populations. Further, we and others have proposed that the learning mechanisms subserved by the cerebellum are critical during development, leading to the hypothesis that cerebellar damage at a younger age would be associated with worse long-term outcomes than damage in adulthood. Based on findings from preterm infants with perinatal cerebellar damage, early cerebellar damage could lead to the atypical development of specific cortical regions to which the cerebellum interconnects in a lesion location-dependent manner. To test these hypotheses, we propose to analyze pre-existing structural imaging and neuropsychological data from ~70 children with a history of pediatric cerebellar tumor. We will conduct multivariate voxel-based lesion-symptom mapping to determine the relationship between lesion location and various motor, cognitive, and behavioral outcome variables; we will specifically examine the impact of age at tumor diagnosis and treatment protocols on these outcomes; and, in patients with longitudinal data, we will examine the impact of age of tumor diagnosis and lesion location on long term outcomes and whole-brain grey and white matter development. The goal of this research is to improve outcome prediction and educational planning in pediatric cerebellar patients. A better understanding of the mechanism(s) by which early cerebellar damage impacts lifelong motor, cognitive, and behavioral development may lead to new interventions to enhance behavioral and neural outcomes for these children.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	AMERICAN UNIVERSITY	4400 MASSACHUSETTS AVE NW	WASHINGTON	DC	20016	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	9/24/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	AMERICAN UNIVERSITY	4400 MASSACHUSETTS AVE NW	WASHINGTON	DC	20016	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	4/1/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $396,041 )
2022	2022	AMERICAN UNIVERSITY, THE	4400 MASSACHUSETTS AVE, NW	WASHINGTON	DC	20016	DISTRICT OF COLUMBIA	USA	Cancer Cause and Prevention Research	000	1	7/15/2022	NEW	$396,041
														Subtotal = $396,041

Grand Total All Awards = $396,041

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Effects of age and lesion location on motor, behavioral and cognitive outcomes in pediatric posterior fossa tumors

Award Number: R15CA271450

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2026

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