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Prebiotic Activity of Pinto Beans Reduces Neuroinflammation in Estrogen Deficiency

Award Number: R15AT011962
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2022
PERIOD OF PERFORMANCE END DATE: 08/31/2026

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Prebiotic Activity of Pinto Beans Reduces Neuroinflammation in Estrogen Deficiency - Project Summary/Abstract: The prevalence of of Alzheimer’s disease (AD) is 2–3 times higher in post-menopausal women and pathology progression and memory impairment is worse in women than men. The rapid decline in circulating estrogen in postmenopausal women has been proposed as a trigger for the development of AD in this population. Previous studies have established a relationship between circulating estrogen levels, gut health including gut microbial population, and brain function. Estrogen deficiency-associated microbial dysbiosis is associated with reduced diversity of gut bacteria (i.e., bacteria with β-glucuronidase activity) that can deconjugate estrogen-containing compounds including phytoestrogens as well as those involved in the production of short chain fatty acids (SCFAs) and tryptophan (Trp) metabolites. Recent studies have identified the influence of SCFAs as well as Trp metabolites in the stimulation and maintenance of brain function. Our parent project is designed to investigate the mechanism through which pinto bean (PB) modulates cardiometabolic outcomes in a mouse model of estrogen deficiency. In this administrative supplement application, we propose to extend that work by examining the effects of PB on the gut-brain axis and subsequent effects on the prevention of neuroinflammation associated with AD in estrogen deficiency, much like the at-risk postmenopausal population. We hypothesize that PB, due to its many bioactive compounds, particularly its Trp and resistant starch (RS) content, will modulate gut microbial composition to maintain gut integrity and increase the production of gut-derived metabolites (i.e., SCFAs and Trp metabolites) consequently improving gut health, reducing neuroinflammation and slowing down the progression of AD in estrogen deficiency. This hypothesis will be tested by: Aim 1: determining the effects of PB and RS on gut microbial composition and gut-derived metabolites and their subsequent effects on markers of neuroinflammation in estrogen deficiency; and Aim 2: investigating the role of β-glucuronidase inhibition combined with PB in the prevention of neuroinflammation in estrogen deficiency. The proposed supplemental study will expand the scope of our current R15 and will now focus to include both metabolic outcomes and prevention of AD in estrogen deficiency. Both studies will provide extensive training opportunities for graduate and undergraduate students, and cross-training between the field of nutrition and brain physiology. Our findings will help advance our understanding of how foods with prebiotic properties such as PB promote health and prevent diseases. Our findings will also help lay the groundwork for future clinical studies, in line with our long-term goal of developing economical, safe and effective strategies for disease prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Research and Training in Complementary and Integrative Health	001	1	8/6/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Research and Training in Complementary and Integrative Health	000	1	8/5/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Research and Training in Complementary and Integrative Health	000	1	8/20/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $168,577 )
2023	2023	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Research and Training in Complementary and Integrative Health	000	1	5/16/2023	SUPPLEMENT FOR EXPANSION	$168,577
														Subtotal = $168,577

Issue Date FY: 2022 ( Subtotal = $369,467 )
2022	2022	OKLAHOMA STATE UNIVERSITY	401 WHITEHURST HALL	STILLWATER	OK	74078	PAYNE	USA	Research and Training in Complementary and Integrative Health	000	1	9/1/2022	NEW	$369,467
														Subtotal = $369,467

Grand Total All Awards = $538,044

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Prebiotic Activity of Pinto Beans Reduces Neuroinflammation in Estrogen Deficiency

Award Number: R15AT011962

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2022

PERIOD OF PERFORMANCE END DATE: 08/31/2026

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