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Role of Distortion Energy in Fibroblast-Mediated Remodeling of Collagen Matrices

Award Number: R15AR075314
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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PROJECT SUMMARY Dense connective tissue is composed of an abundant collagen network that is maintained and repaired by fibroblasts. The parent R15 proposal is investigating whether fibroblast-mediated collagen remodeling is governed at the tissue-scale by distortion strain energy. The effect of targeted magnitudes of distortion energy on collagen remodeling will be measured by quantifying alterations in the composition, organization, and mechanical behavior of the scaffolds. In order to quantify changes in fiber organization from confocal microscopy images, a software application called FiberFit is being used to automate the objective measurement of two structural properties that describe material anisotropy: fiber orientation and fiber dispersion. The standalone software application, FiberFit, was developed in the Northwest Tissue Mechanics laboratory in 2016 and is freely available to the scientific community for Windows and Mac systems. FiberFit has now been used in many research projects outside the developing laboratory, including research on tumors, liver, muscle, and engineered composite materials. This project will re-engineer FiberFit and deploy it as a cloud-based application. Emphasis will be placed on creating a robust, intuitive, and sustainable software application that implements best practices in software engineering and design to facilitate broad adoption across the scientific community.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$14 )
2025	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	12/16/2024	SUPPLEMENT FOR EXPANSION	-$14
														Subtotal = -$14

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	7/27/2023	SUPPLEMENT FOR EXPANSION	$0
2023	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/27/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $113,546 )
2021	2021	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	9/23/2021	SUPPLEMENT FOR EXPANSION	$113,546
														Subtotal = $113,546

Issue Date FY: 2019 ( Subtotal = $393,704 )
2019	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	1	8/22/2019	NEW	-$12,325
2019	2019	BOISE STATE UNIVERSITY	1910 UNIVERSITY DR	BOISE	ID	83725	ADA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	8/13/2019	NEW	$406,029
														Subtotal = $393,704

Grand Total All Awards = $507,236

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Role of Distortion Energy in Fibroblast-Mediated Remodeling of Collagen Matrices

Award Number: R15AR075314

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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