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New Targets for Vector Control: Regulation of Female Behavior and Physiology byAdipokinetic Hormone in Aedes aegypti

Award Number: R15AI140223
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 07/31/2023

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New Targets for Vector Control: Regulation of Female Behavior and Physiology byAdipokinetic Hormone in Aedes aegypti - Project Summary Seminal fluid molecules (SFMs), which are produced by males and transferred to females during mating, have profound impacts on the feeding, reproduction, and lifespan of female insects, including Aedes aegypti and Ae. albopictus, the main vectors of several viruses that are devastating to human health. Identifying the individual bioactive SFMs and their mode of action in Aedes mosquitoes will provide new pathways and tools for stemming disease spread by this species. We have carefully laid the groundwork for such investigations by identifying seminal fluid proteins in both Ae. aegypti and Ae. albopictus. We are now poised to investigate the functions of individual seminal fluid proteins in regulating female behavior and physiology. One of the proteins we discovered in the seminal fluid is adipokinetic hormone (AKH). Across a range of insects, AKHs’ effects include modulating insect response to nutritional stress by inducing release of nutrients from the fat body, mediating oxidative stress, and regulating egg production, feeding, and digestion. AKH’s role in Aedes mosquitoes is unknown and AKH. Given the effects of AKHs in other insects, we hypothesize that seminal fluid-derived AKH is important in regulating the post-mating changes in nutrition-related phenotypes observed in Aedes females. We will test this hypothesis by testing the effect of eliminating seminal fluid AKH on female post-mating responses. In Aim I, we will compare female blood feeding, blood digestion, egg production, and longevity between females mated to wildtype and AKH-null males. In Aim 2, we will identify the location of the receptors within females that bind seminal fluid AKH. In Aim 3, we will determine what genes and molecular pathways are regulated by receipt of seminal fluid AKH. The experiments outlined here will identify behavioral and physiological phenotypes and molecular pathways that are manipulatable through exogenous signaling. Further, they will expand our understanding of the role of adipokinetic hormones. Finally, this proposal will provide outstanding research and training opportunities for many undergraduate students allowing them to learn techniques in studying behavior, physiology, molecular biology, neurobiology, and biochemistry. The PI and the consultants on the project have extensive experience training undergraduates in these techniques. Each aim is divided into proposed experiments that are within the scope of a typical individual thesis project at the College of Wooster or could be completed by multiple students working collaboratively on different aspects of the experiment. Such collaborative projects would expose students to a wider range of approaches and methodologies than would be possible if they were working independently. Thus, the funding provided by this grant would greatly strengthen the research experiences and collaborative opportunities for students across the life sciences at The College of Wooster and prepare these students to take integrative multi-disciplinary approaches to problem solving in the careers they pursue after graduation.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$956 )
2024	2019	THE COLLEGE OF WOOSTER	1101 N BEVER ST	WOOSTER	OH	44691	WAYNE	USA	Allergy and Infectious Diseases Research	000	1	6/10/2024	NEW	-$956
														Subtotal = -$956

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2019	COLLEGE OF WOOSTER, THE	1101 N BEVER ST	WOOSTER	OH	44691	WAYNE	USA	Allergy and Infectious Diseases Research	000	1	6/15/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $0 )
2020	2019	THE COLLEGE OF WOOSTER	1189 BEALL AVE	WOOSTER	OH	44691	WAYNE	USA	Allergy and Infectious Diseases Research	000	1	2/6/2020	NEW	$0
														Subtotal = $0

Issue Date FY: 2019 ( Subtotal = $323,901 )
2019	2019	THE COLLEGE OF WOOSTER	1189 BEALL AVE	WOOSTER	OH	44691	WAYNE	USA	Allergy and Infectious Diseases Research	000	1	7/29/2019	NEW	$323,901
2019	2019	THE COLLEGE OF WOOSTER	1189 BEALL AVE	WOOSTER	OH	44691	WAYNE	USA	Allergy and Infectious Diseases Research	001	1	8/9/2019	NEW	$0
														Subtotal = $323,901

Grand Total All Awards = $322,945

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New Targets for Vector Control: Regulation of Female Behavior and Physiology byAdipokinetic Hormone in Aedes aegypti

Award Number: R15AI140223

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 07/31/2023

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