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Paratransgenesis for malaria using Asaia sp. bacteria

Award Number: R15AI107735
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2014
PERIOD OF PERFORMANCE END DATE: 01/31/2024

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Paratransgenesis for malaria using Asaia sp. bacteria - PROJECT SUMMARY/ABSTRACT Malaria is a disease caused by protozoan parasites that are transmitted to humans by mosquitoes in the genus Anopheles. There are nearly 220 million new cases of malaria every year, and 500,000 people die from the disease while millions of others are severely debilitated (2016 data). About half the human population is at risk of contracting malaria, and its range may spread as global warming accelerates. The broad, long term objectives of this proposal are to create new methods of combating malaria to complement the current methods of control, namely insecticides to kill mosquito vectors and drugs to kill parasites in infected people. This project seeks to develop the means to create strains of bacteria that can interfere with the ability of mosquitoes to transmit malaria thus reducing its overall health burden and aiding in the goal of eradicating this disease. The specific aims of this research project are as follows: Aim 1. Creation of genetically-stable antimalarial strains of Asaia bogorensis For eventual field use, paratransgenic strains of Asaia must be genetically stable. Because these systems cannot be based on laboratory plasmids that use drug selection, we will develop methods to create strains that contain genes that are inserted in the chromosome or are borne on plasmids that require no drug selection and that cannot be horizontally transferred to other bacteria. Aim 2. Assessing combinations of antimalarial effector genes for effectiveness against Plasmodium. Field strains of Asaia will have to express multiple antiplasmodial effector gene encoding products that act against parasites by different routes to avoid the evolution of resistance by the parasites. We will evaluate different combinations of effector genes in the same strain of Asaia for effectiveness at killing Plasmodium and for their effect on the fitness of the Asaia strains.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$833 )
2024	2020	DUQUESNE UNIVERSITY OF THE HOLY SPIRIT	600 FORBES AVENUE	PITTSBURGH	PA	15282	ALLEGHENY	USA	Allergy and Infectious Diseases Research	000	2	7/29/2024	COMPETING CONTINUATION	-$833
														Subtotal = -$833

Issue Date FY: 2020 ( Subtotal = $410,135 )
2020	2020	DUQUESNE UNIVERSITY OF THE HOLY SPIRIT	600 FORBES AVE STE 205	PITTSBURGH	PA	15219	ALLEGHENY	USA	Allergy and Infectious Diseases Research	001	2	2/3/2020	COMPETING CONTINUATION	$410,166
2020	2014	DUQUESNE UNIVERSITY OF THE HOLY SPIRIT	600 FORBES AVE STE 205	PITTSBURGH	PA	15219	ALLEGHENY	USA	Allergy and Infectious Diseases Research	000	1	10/1/2019	NEW	-$31
														Subtotal = $410,135

Issue Date FY: 2019 ( Subtotal = $0 )
2019	2014	DUQUESNE UNIVERSITY OF THE HOLY SPIRIT	600 FORBES AVE STE 205	PITTSBURGH	PA	15219	ALLEGHENY	USA	Allergy and Infectious Diseases Research	000	1	1/3/2019	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $0 )
2018	2014	DUQUESNE UNIVERSITY OF THE HOLY SPIRIT	600 FORBES AVE STE 205	PITTSBURGH	PA	15219	ALLEGHENY	USA	Allergy and Infectious Diseases Research	000	1	6/6/2018	NEW	$0
														Subtotal = $0

Issue Date FY: 2014 ( Subtotal = $396,000 )
2014	2014	DUQUESNE UNIVERSITY OF THE HOLY GHOST	ADMINISTRATION BLDG, ROOM 211	PITTSBURGH	PA	15282	ALLEGHENY	USA	Allergy and Infectious Diseases Research	000	1	7/25/2014	NEW	$396,000
														Subtotal = $396,000

Grand Total All Awards = $805,302

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Paratransgenesis for malaria using Asaia sp. bacteria

Award Number: R15AI107735

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2014

PERIOD OF PERFORMANCE END DATE: 01/31/2024

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