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A Role for the Astrocytic Network in Spatial Navigation

Award Number: R15AG075587
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 02/15/2022
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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A Role for the Astrocytic Network in Spatial Navigation - Spatial navigation affords an adaptive advantage for all animal species, optimizing chances of survival and reproduction. This behavior involves a multitude of brain structures and cognitive functions, starting from perception of self-motion and environmental cues, to building spatial representations and goal integration. The hippocampus formation is particularly important for the building, maintaining, and updating spatial maps for navigation and planning. This project will explore the role of hippocampal astrocytic networks in spatial navigation and aging-related spatial navigation deficits. We will develop pharmacological manipulations to rescue behavioral deficits in aged mice. The project will enhance our understanding of the role of the hippocampal anatomy and connectivity in spatial navigation, the biological processes underlying behavioral deficits in aged individuals, and will help develop new remedial strategies in animal models, with possible subsequent impact on clinical treatments.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HL	LOGAN	UT	84322	CACHE	USA	Aging Research	000	1	5/5/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $438,000 )
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Aging Research	001	1	9/20/2022	NEW	$0
2022	2022	UTAH STATE UNIVERSITY	1000 OLD MAIN HILL	LOGAN	UT	84322	CACHE	USA	Aging Research	000	1	2/15/2022	NEW	$438,000
														Subtotal = $438,000

Grand Total All Awards = $438,000

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A Role for the Astrocytic Network in Spatial Navigation

Award Number: R15AG075587

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 02/15/2022

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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