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Identifying biomarkers for the early detection of Alzheimer's disease using phage display

Award Number: R15AG066122
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2020
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Identifying biomarkers for the early detection of Alzheimer's disease using phage display - Project Summary The long-term goal of this study is to develop a biomarker-based screening assay for the early detection of AD-related biochemical changes that can be measured in biofluids such as the CSF. The main goal of this study is to identify phage-based probes to novel protein metabolites associated with AD and its progression. This study will have multiple positive effects that include: earlier and more accurate diagnosis and improved ability to monitor disease progression. To accomplish this goal the project has two aims: Aim. Identify phage with high sensitivity and specificity for AD-related post-translational modifications (PTMs) to selected proteins associated with AD. This aim will leverage the power of phage display to identify novel biomarkers within a selected group of proteins previously found to be associated with AD. Preliminary data demonstrate the proposed method is sufficient to differentially identify even closely related metabolites as well as differentiate between a pilot group of clinically diagnosed AD and control subjects. Alzheimer’s disease is a slow, progressive neurodegenerative disease that ultimately results in death. It is the 6th leading cause of death in the U.S. and there is no cure. Currently, diagnosis occurs relatively late in the, and many cases of AD are misdiagnosed. This proposal addresses an important gap in the development of robust biomarker arrays to assist in the more accurate and earlier detection of AD-related dementia. Completion of this study would be the first step to create PTM based array to evaluate the range of AD-relevant biomarkers to further improve the accuracy of diagnosis and monitoring of disease progression.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $421,497 )
2024	2024	UNIVERSITY OF WEST FLORIDA	1100 UNIVERSITY PKWY BLDG 20E 108	PENSACOLA	FL	32514	ESCAMBIA	USA	Aging Research	001	2	7/29/2024	COMPETING CONTINUATION	$358,473
2024	2024	UNIVERSITY OF WEST FLORIDA	1100 UNIVERSITY PKWY BLDG 20E 108	PENSACOLA	FL	32514	ESCAMBIA	USA	Aging Research	002	2	8/6/2024	COMPETING CONTINUATION	$63,027
2024	2020	UNIVERSITY OF WEST FLORIDA	1100 UNIVERSITY PKWY BLDG 20E 108	PENSACOLA	FL	32514	ESCAMBIA	USA	Aging Research	000	1	12/4/2023	NEW	-$3
														Subtotal = $421,497

Issue Date FY: 2020 ( Subtotal = $423,000 )
2020	2020	UNIVERSITY OF WEST FLORIDA	11000 UNIVERSITY PKWY BLDG 10	PENSACOLA	FL	32514	ESCAMBIA	USA	Aging Research	000	1	2/18/2020	NEW	$423,000
														Subtotal = $423,000

Grand Total All Awards = $844,497

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Identifying biomarkers for the early detection of Alzheimer's disease using phage display

Award Number: R15AG066122

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2020

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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