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Effects of cholinergic axonal plasticity on spatial orientation

Award Number: R15AG060613
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Effects of cholinergic axonal plasticity on spatial orientation - Project Summary/Abstract Neurodegenerative disorders can produce significant impairments in a patient’s ability to maintain spatial orientation. The current changing age structure of the US population in combination with lack of effective treatments for neurodegenerative disorders presents serious challenges for society in the management of these patients. Evaluating novel therapies for neurodegenerative disorders will depend on identifying an appropriate animal model of spatial orientation. Rats, like humans, use environmental and self-movement cues to maintain spatial orientation. My research has focused on developing tasks for rats that dissociate the use of either source of information. The basal forebrain cholinergic projections undergoes significant degeneration during the progression of Dementia of the Alzheimer's Type. The experiments outlined in this proposal represent the next step in investigating the potential of enhancing neuroplasticity to improve cognitive deficits associated with pathology in the basal forebrain cholinergic neurons. One goal of the proposal examines whether anti-Nogo-A immunotherapy is sufficient to promote neuroplasticity basal forebrain cholinergic neurons in adult and senescent rats. Another goal is to evaluate the extent that enhanced neuroplasticity at either age is sufficient to ameliorate self-movement cue processing deficits. A final goal is to provide training experiences for undergrad and graduate students that will establish a foundation to pursue a career in the biomedical sciences. The results of these studies will advance our understanding of the effects of aging on spatial orientation and evaluate the potential of anti-Nogo-A immunotherapies as a novel intervention for neurodegenerative disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2018	NORTHERN ILLINOIS UNIVERSITY	1425 W LINCOLN HWY	DE KALB	IL	60115		USA	Aging Research	000	1	4/25/2022	NEW	$0
														Subtotal = $0

Issue Date FY: 2018 ( Subtotal = $408,171 )
2018	2018	NORTHERN ILLINOIS UNIVERSITY	1425 W LINCOLN HWY	DE KALB	IL	60115		USA	Aging Research	000	1	7/13/2018	NEW	$408,171
														Subtotal = $408,171

Grand Total All Awards = $408,171

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Effects of cholinergic axonal plasticity on spatial orientation

Award Number: R15AG060613

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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