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Neuroimmune behaviorial effects of CB2 cannabinoid receptors

Award Number: R15AA027909
ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/25/2020
PERIOD OF PERFORMANCE END DATE: 08/31/2024

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Neuroimmune behaviorial effects of CB2 cannabinoid receptors - PROJECT SUMMARY/ABSTRACT The neuronal function of CB2 cannabinoid receptors (CB2Rs) has been less investigated for central nervous system function, because CB2Rs were thought to be predominantly in immune cells in the periphery and were called peripheral CB2Rs. The available CB2R gene knock (KO) mice are partial KO mice that are not suitable for tissue- and cell-type specific behavioral, molecular and pharmacological studies. The purpose of this study is to determine the functional role(s) of CB2Rs in the nervous and immune system using CB2R conditional knockout (cKO), Cx3cr1-Cnr2 and DAT-Cnr2 mice that we have created and produced, and validated the F2 generation for the deletion of CB2Rs in microglia and dopamine (DA) neurons respectively. In this proposal, we test the hypothesis that CB2Rs expressed in microglia cells and dopamine neurons differentially modulate behavioral responses in the CB2R cKO mice models. This hypothesis will be tested in-vivo and in-vitro in the CB2R cKO mice with the following specific aims including the Institutional objective. 1) determine the behavioral effects and functional role of CB2Rs in the CB2 cKO, Cx3cr1-Cnr2 and DAT-Cnr2 mice and their controls; 2) define the neuro-immuno-activity of CB2Rs in microglia and DA neurons; and 3) provide research training opportunities to students and strengthen research environment at a predominantly undergraduate institution. The results will provide insights into the behavioral effects associated with the modulation of CB2Rs and a mouse model to screen cannabinoids and other classes of drugs for conditions of neuro-immune disorders.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2020	WILLIAM PATERSON UNIVERSITY OF NEW JERSEY	300 POMPTON RD	WAYNE	NJ	07470	PASSAIC	USA	Alcohol Research Programs	000	1	1/3/2025	NEW	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2020	WILLIAM PATERSON UNIVERSITY OF NEW JERSEY	300 POMPTON RD	WAYNE	NJ	07470	PASSAIC	USA	Alcohol Research Programs	000	1	9/27/2023	NEW	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $412,202 )
2020	2020	WILLIAM PATERSON UNIVERSITY OF NEW JERSEY	300 POMPTON RD	WAYNE	NJ	07470	PASSAIC	USA	Alcohol Research Programs	000	1	9/22/2020	NEW	$412,202
														Subtotal = $412,202

Grand Total All Awards = $412,202

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Neuroimmune behaviorial effects of CB2 cannabinoid receptors

Award Number: R15AA027909

ORGANIZATION: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/25/2020

PERIOD OF PERFORMANCE END DATE: 08/31/2024

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