Saturday, November 23, 2024
11/23/2024
ABSTRACT Support is requested for a Keystone Symposia conference entitled Proximity Based Therapeutics, organized by Drs. Ryan Potts and Michelle Arkin. The conference will be held in Copper, Colorado from January 21-24, 2024. Drug discovery is undergoing a revolution that moves away from occupancy-driven pharmacology to proximity- based therapeutics that take advantage of event driven pharmacology. Induced proximity medicines or “multi- specifics” mobilize a cell’s natural biological mechanisms to operate on disease-causing proteins by bringing together these proteins with cellular effectors capable of regulating target activity or abundance. Proximity based therapeutics have the potential to unlock new target space and make significant inroads to drug the “undruggable” genome. This conference will focus on understanding the opportunities and challenges in this exciting new area. The program includes topics such as: 1) Controlling Post-Translational Modifications by Induced Proximity; 2) Emerging Proximity Biology for Target Degradation; 3) Stabilizing Protein-Protein Interactions with Molecular Glues; and 4) Predicting and Discovering Ternary Complexes. The conference program is designed to bring together interdisciplinary groups of scientists, including biologists and chemists, from both academic and industry to explore the latest findings in this field and accelerate its growth. Finally, this conference will be held jointly with Targeted Protein Degradation. This pairing will lead to synergistic interactions between these two communities and will enhance momentum in basic and translation research, while providing networking and career development opportunities at shared meals and poster sessions.
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