2025 Cilia, Mucus and Mucociliary Interactions Gordon Research Conference and Gordon Research Seminar - PROJECT SUMMARY This application seeks support for a Gordon Research Conference (GRC) and corresponding Gordon Research Seminar (GRS) on Cilia, Mucus and Mucociliary Interactions from February 16-21, 2025, in Pomona, CA. This is a highly integrated and unique meeting that unites basic scientists, bioengineers, translational investigators, and clinicians who study the components and fundamentals of cilia and mucus biology, their interface as a mucociliary apparatus, and human diseases related to mucociliary dysfunction. Mucociliary clearance (MCC) is essential for respiratory tract defense against inhaled pathogens. MCC dysfunction leads to infections and complications in common conditions such as asthma through to rare genetic disorders, including cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). Advancing technologies have led to growing knowledge of the assembly and function of cilia, the production and secretion of mucin glycoproteins, and the cilia-mucus interactions required for MCC. These innovations stem from the ongoing work of established teams and new entrants, including young investigators. Thus, a central element of this meeting focuses on promoting the visibility of trainees and young investigators within the field, as well as championing women and minority researchers, thus aligning with GRC and NIH missions. A cohesive program is proposed to enhance the interplay between specialized disciplines that seek to integrate knowledge and impact advances in biochemistry, biophysics, cell biology, development, genetics, and translational research of respiratory tract diseases. The GRS and GRC leadership teams share a common vision of fostering an innovative, informative, and integrated forum for discussing novel research and current challenges in mucociliary biology. The conference will emphasize the following scientific themes: a) genetic and gene regulatory mechanisms of mucociliary components, b) structure and function of mucin glycoprotein polymers and motile cilia, c) secretion of mucins and mechanics of ciliary activity, d) the effects of mucociliary function and dysfunction on host physiology and pathophysiology, and e) the on-going application of cilia and mucus biology to develop promote respiratory health and reduce the burden of disease. With this approach, we seek to achieve three Specific Aims: 1) To disseminate, discuss, and integrate the latest, unpublished, cutting-edge data on cilia, mucus and mucociliary interactions in a forum of world experts and early career scientists; 2) to provide a platform that links fundamental scientific knowledge related to cilia, mucus, and mucociliary interactions to human disease and avenues for diagnosis and therapies; and 3) to facilitate and promote the involvement and advancement of underrepresented minorities, women, and trainees across aspects of mucociliary interactions, through top-down program choices to increase global representation, as well as bottom-up initiatives including childcare grants and Carl Storm fellowships to mitigate barriers to more inclusive audiences.
