2024 Angiotensin Gordon Research Conference and Seminar - PROJECT SUMMARY The 2024 GRC on Angiotensin will focus on the latest advances in the RAAS, from discovery science to clinical impact. The highlight will be the interplay between RAAS and other hormonal systems and how this influences interorgan communications from cell signaling to systems biology, and the implications in drug discovery. We will discuss interactions between the RAAS and other hormonal and biological systems, the mechanisms of systems crosstalk, and its effects on inter-organelle and inter-organ communications to reveal the role of the RAAS across systems. Growing evidence indicates extensive communication between distant organs in health and disease. Examples include axes between gut-brain, heart-kidneys, heart-brain, liver-heart, adipose-vascular, and immune-cardiovascular. Preceding the GRC, is the 2024 Gordon Research Seminar (GRS), a unique forum organized by junior investigators for graduate students, postdoctoral fellows, and early career researchers, to present and exchange new data and cutting-edge ideas. The GRS will focus on sharing knowledge of recent tools and breakthroughs to explore the RAAS system in the pathophysiology of cardiovascular diseases. The mentoring block will emphasize career development and provide a session to discuss important aspects such as grant writing and self-management. Moreover, it offers a one-to-one meeting with a mentor to discuss career planning. Our scientific program is designed to attract a new broader community, including scientists, clinical researchers, biomedical engineers, computational biologists, and data scientists from across the world, and will facilitate opportunities for networking between diverse disciplines. The theme of the GRC is ‘The Interplay Between the RAAS and Other Hormonal Systems: From Cell Signaling to Novel Therapies,’ and the specific aims are to: 1. Highlight the interplay between the RAAS and other hormonal systems and how this influences interorgan communications from cell signaling to systems biology and the implications in drug discovery. 2. Discuss the mechanisms of systems crosstalk and its effects on inter-organelle and interorgan communications will reveal the role of the RAAS across systems. This is especially important because growing evidence indicates extensive communication between distant organs in health and disease. 3. Foster mentoring and networking among trainees, women, under-represented minorities, undergraduate and graduate students, postdoctoral fellows, early career scientists, and expert investigators in the RAAS field. 4. Facilitate career-planning for junior scientists and help successful development in basic, clinical, and translational sciences in the RAAS field.
