ABSTRACT
Support is requested for a Keystone Symposia conference entitled Sleep and Circadian Biology - Maintaining
Tempo for Optimal Health, organized by Drs. Marie-Pierre St-Onge, Eve Van Cauter, Christian Benedict and
Jonathan Cedernaes. The conference will be held in Novato, California from October 10-13, 2022.
Altered lifestyle behaviors (e.g., shift work, jet lag, delayed sleep and meal timing) disrupt sleep and impair
circadian rhythms, resulting in dysregulation of important physiological and psychological parameters such as
blood pressure, glucose, hormones, and vigilance, thereby contributing to increased chronic disease burden,
and increased risk of cancer, cardiovascular disease, cognitive impairment and accelerated aging. However,
there is a need to bridge sleep and circadian biology scientists to foster dialogues for advancing research in
these fields. The goal of this conference is to bring together scientists studying the timing of lifestyle behaviors,
including sleep, food intake, and exercise, on chronic disease risk to uncover important next steps for this
research area. This conference will cover concepts related to sleep, circadian rhythms, and chronobiology.
Concepts will not only cover the biology of sleep and circadian rhythms, such as genetic and hormonal
controls, but also how behaviors alter sleep and circadian rhythms, and how these changes challenge our
biological systems and impart negative consequences on health. Importantly, this conference will cover the bi-
directional relationship between lifestyle behaviors, health outcomes, and sleep and circadian rhythms. As a
result, the field will be energized with new avenues for collaborations, research, and knowledge.