Monday, June 23, 2025 6/23/2025

FASEB SRC on The Biology of Cilia and Flagella

Award Number: R13HD098854
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2019
PERIOD OF PERFORMANCE END DATE: 05/31/2024

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FASEB SRC on The Biology of Cilia and Flagella - Abstract Cilia and flagella are thread-like cell organelles protruding from the cell surface into the environment. Long neglected, research on the biology of cilia has seen tremendous growth over the last two decades as their central role in cellular sensing and human disease emerged. Defective cilia cause multi-organ disorders such as Bardet-Biedl, Meckel Gruber, and Joubert syndrome. Cilia participate in several signaling pathways including vertebrate Hedgehog signaling, which is critical for embryonic development and has been implicated in certain cancers including basal cell carcinomas and medulloblastomas, the most common brain tumor in juveniles. G-protein coupled receptors have key roles in mammalian sensing and signaling and many of the receptors are located in cilia. Sensing of light and odors, for example, occurs in cilia and cilia-based receptors have been implicated in the control of appetite, behavior and vision. Thus, ciliary dysfunction contributes to common diseases such as blindness, diabetes and obesity. The purpose of this proposal is to support the participation of junior scientists studying cilia biology and cilia-related disease at the FASEB Summer Research Conferences on the Biology of Cilia and Flagella in 2019, 2021 and 2023. The FASEB conference on cilia and flagella is the premier international meeting on cilia signaling and cilia-related disease. The conference brings together cell, molecular, and developmental biologists, human geneticists, biochemists, physician scientists and biophysicists with interests ranging from the fundamental biology of cilia to the genetics and molecular mechanisms of human cilia-based diseases and their treatment options. In this proposal, we request funds to support junior scientists and investigators, who have not participated in this FASEB conference before, to attend as speakers to promote growth and innovation of the field. A Meet-the-Experts session will be held at the first day of the meeting to facilitate informal interaction between senior members of the field meet and junior scientists and newcomers. We will invite representatives from industry, foundations, teaching colleges and publishing to participate in three workshops on career development and options in and outside of academia. This international meeting is very well attended by postdocs and early stage investigators as well as established experts in the field. This mix of attendees will further the goal of the conference of generate research collaborations, identify key challenges in the field, and stimulate innovative research on the biology of cilia, cilia-related disease and therapies.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$3,691 )
2025	2023	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	6120 EXECUTIVE BLVD STE 575	ROCKVILLE	MD	20852	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	5	10/17/2024	NON-COMPETING CONTINUATION	-$3,691
														Subtotal = -$3,691

Issue Date FY: 2023 ( Subtotal = $16,000 )
2023	2023	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	6120 EXECUTIVE BLVD	ROCKVILLE	MD	20852	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	5	6/1/2023	NON-COMPETING CONTINUATION	$16,000
														Subtotal = $16,000

Issue Date FY: 2022 ( Subtotal = $1 )
2022	2022	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	6120 EXECUTIVE BLVD STE 600	ROCKVILLE	MD	20852	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	4	6/3/2022	NON-COMPETING CONTINUATION	$1
														Subtotal = $1

Issue Date FY: 2021 ( Subtotal = $16,000 )
2021	2021	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	3	6/10/2021	NON-COMPETING CONTINUATION	$16,000
														Subtotal = $16,000

Issue Date FY: 2020 ( Subtotal = $1 )
2020	2020	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	001	2	4/17/2020	NON-COMPETING CONTINUATION	$1
2020	2019	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	1	3/13/2020	NEW	$0
														Subtotal = $1

Issue Date FY: 2019 ( Subtotal = $15,000 )
2019	2019	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	000	1	5/14/2019	NEW	$10,000
2019	2019	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	003	1	8/2/2019	NEW	$3,000
2019	2019	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	001	1	7/31/2019	NEW	$0
2019	2019	FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY	9650 ROCKVILLE PIKE	BETHESDA	MD	20814	MONTGOMERY	USA	Child Health and Human Development Extramural Research	002	1	8/1/2019	NEW	$2,000
														Subtotal = $15,000

Grand Total All Awards = $43,311

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FASEB SRC on The Biology of Cilia and Flagella

Award Number: R13HD098854

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2019

PERIOD OF PERFORMANCE END DATE: 05/31/2024

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