2025 IGF and Insulin System in Physiology and Disease Gordon Research Conference and Gordon Research Seminar - Abstract The Gordon Research Conferences (GRCs) stand at the forefront of fostering innovative, unpublished research. This esteemed conference unites leading scientists, emerging scholars, and students, dedicated to advancing our understanding of the Insulin-like Growth Factor (IGF) axis—a critical regulator of development, aging, and metabolism, and its dysregulation's link to diseases such as cancer, diabetes, and cardiovascular conditions. The 2025 conference is set to delve into the dual nature of IGF-1, exploring its beneficial and detrimental effects across life stages and seeking interventions to address existing knowledge gaps. It uniquely focuses on the endocrine, paracrine, and autocrine roles of IGF and insulin, aligning with the NIDDK’s objectives to cover a spectrum of topics from receptor signaling to its impact on gene activity in metabolic organs. A key feature of this conference is its focus on the latest research on IGF/insulin's role in inflammation, metabolism, stem cell influence, and its connection to health span and cancer. The inclusion of clinical experts to discuss new human mutations within the IGF axis marks a significant addition to this year's agenda. Objectives of the conference include promoting comprehensive dialogue among experts and newcomers, encouraging global collaboration across continents, and advancing junior investigators through mentorship and networking opportunities. These objectives are meticulously integrated into the conference structure, from Power Hours focusing on diversity and inclusion to career development workshops and intimate sessions with leading experts. The impact of the 2025 IGF GRC extends beyond scientific discourse; it is a vital incubator for innovation, mentorship, and professional development within the NIDDK community. By emphasizing open dialogue, collaboration, and inclusivity, the conference aims to catalyze groundbreaking research and future advancements in IGF and insulin research. It underscores the importance of community, collaboration, and career development in propelling scientific progress, making it a pivotal event for shaping the future trajectory of IGF-1 and insulin research.
