Obesity: Causes and Consequences - ABSTRACT Support is requested for a Keystone Symposia conference entitled Obesity: Causes and Consequences, organized by Drs. Giles S.H. Yeo, Karine Clément and Murielle Véniant-Ellison. The conference will be held in Vancouver, British Columbia, Canada from February 4-7, 2024. Over the last four decades, the prevalence of obesity has tripled in the population. Along with its wide range of comorbidities, obesity is associated with a substantial proportion of the worldwide non-communicable disease burden. In parallel, the emergence of innovative therapies is transforming the field of obesity. This Keystone Symposia conference is designed to explore the latest research focused on the causes of obesity, including genetics, environmental impacts, and hypothalamic dysfunction, as well as how the heterogeneity of obesity affects the field’s approach to its precision management. The sessions also emphasize the metabolic consequences of obesity, including Type 2 Diabetes (T2D), dyslipidemia, as well as cardiovascular, liver and renal disease. Finally, the program will touch on innovation in treatment and new molecular targets. While the value of model organisms is recognized in the field, this program was designed to focus on the model that matters most: humans. This conference will be paired with another Keystone Symposia conference entitled Cardiometabolic Diseases: The Role of Ethnic Diversity in Precision Medicine, where shared scientific sessions will explore cross connectivity of genetics and precision obesity management. These joint conferences will also bring together an interdisciplinary group of investigators with different focus areas within the field, ranging from ‘big data’ to detailed mechanistic studies. Participants of both conferences will also have an opportunity to network at shared meals and poster sessions. This unique environment will lead to new scientific collaborations and the implementation of precision medicine approaches directed at better understanding and treating cardiometabolic disease.