ABSTRACT
Support is requested for a Keystone Symposia conference entitled Functional Neurocircuitry of Feeding and
Feeding Behavior, organized by Drs. Roger D. Cone, Lori M. Zeltser and Matthew R. Hayes. The conference
will be held in Banff, Canada from February 10-14, 2019.
The Keystone Symposia conference on neuronal control of appetite is a well-attended conference that is the
leading gathering for scientific exchange among those studying the central control of energy homeostasis. The
monogenetic syndromes of obesity in mouse and man played a fundamental role in the development of this
field, and hence the field has heavily emphasized the control of feeding in models of obesity. However, many
disorders of feeding and energy storage, including anorexia nervosa, disease cachexia, pediatric failure to
thrive, Prader-Willi disease and progeria are important untreated medical conditions. The goal of this
conference will be to gather world leaders in the neural control of feeding and energy homeostasis, along with
leaders in the pathophysiology of feeding and energy homeostasis. There is currently no conference in the field
that brings together these disparate groups of scientists. For example, recent annual conferences of the
Society for the Study of Ingestive Behavior had few talks on anorexia or cachexia. The 2017 Keystone
Symposia conference on Neural Control of Appetite began to expand the biological breadth of feeding
behaviors under investigation, and this proposed conference will further broaden this field by covering
fundamental advances in the neural circuitry underlying feeding, while including entire sessions devoted to
anorexia nervosa, disease cachexia, and feeding disorders across the lifespan. Additionally, while the
Keystone conference on Obesity and Adipose Tissue Biology has been heavily focused on the hypothalamic
control of homeostatic feeding, this conference will have entire sessions devoted to brainstem and
telencephalic control of feeding.