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Chemistry and Pharmacology of Drugs of Abuse Annual Symposium

Award Number: R13DA040423
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 07/15/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Chemistry and Pharmacology of Drugs of Abuse Annual Symposium - OTHER PROJECT INFORMATION – PROJECT SUMMARY/ABSTRACT This proposal is a renewal for the tremendously successful two-day symposium “Chemistry and Pharmacology of Drugs of Abuse” (CPDA) symposium that first took place in 2016 under the auspices of the Center for Drug Discovery (CDD), Northeastern University, Boston, Massachusetts. The primary aim of the symposium is to serve as an interdisciplinary exposition of the most recent, important, research-related advances in (pre)clinical research related to Substance Use Disorder (SUD). Substance Use Disorders (SUDs) and addiction are pervasive threats to global public health and the nature of the threat is ever evolving and changing. Our goal is to address gaps in current knowledge concerning SUD disease mechanisms and treatments that are at the root of our limitations in solving these medical challenges. A major theme is the integration of medicinal chemistry, structural biology, pharmacology, behavioral pharmacology and clinical practice to inform the design, synthesis, optimization, and (pre)clinical profiling of new agents for their therapeutic potential. SUD biology and etiology are complex. Behavioral, environmental, and (epi)genetic factors conspire to modulate neuronal circuits to affect vulnerability, cognition, social behavior, and emotional state in ways that help establish a SUD phenotype. The details of these neurobiological processes are not well understood. In addition, better standardized animal paradigms of drug-seeking and -taking are required that better model clinical SUD pathology and can be used to accurately assess the potential of novel SUD drugs. Despite significant advances, there is a frustratingly limited number of safe and affective pharmacotherapies available to attain durable abstinence. Our continuing aim is to focus the meeting entirely on Substance Use Disorder and bring together leading practitioners from each of these fields. Moreover, there are emergent threats to at-risk SUD populations such as “designer drugs” that lack affective pharmacotherapy and require ongoing vigilance and effort to combat. We aim to include topics that address emergent issues in each year’s program as identified by NIDA community leaders and leading research. Such a gathering offers a rich opportunity to expose young scientists to the field. We aim to inspire and encourage the next generation of researchers to devote themselves to this endeavor. We have made considerable efforts to welcome scientists from underserved and underrepresented populations and we aim to expand these efforts. A focused meeting on SUD responsive to emergent threats is of high value and has garnered much support by the SUD research community and diverse constituencies, from basic researchers to healthcare providers and public-health officials. This included scientists from biotechnology (e.g. Astraea Therapeutics), leading biomedical research centers (e.g. Scripps Research Institute), research-intensive clinical centers (e.g., McLean Hospital/Harvard Medical School, Icahn School of Medicine at Mount Sinai) and representatives from the City of Boston Mayor’s office. Our goal is to further raise the public profile of our symposium.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $25,000 )
2024	2024	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	10	6/14/2024	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2023 ( Subtotal = $25,000 )
2023	2023	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	9	6/30/2023	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2022 ( Subtotal = $25,000 )
2022	2022	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	002	8	6/16/2022	NON-COMPETING CONTINUATION	$25,000
2022	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	6	11/1/2021	COMPETING CONTINUATION	$521
2022	2019	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	5	11/1/2021	NON-COMPETING CONTINUATION	-$521
														Subtotal = $25,000

Issue Date FY: 2021 ( Subtotal = $25,000 )
2021	2021	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	7	7/2/2021	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2020 ( Subtotal = $25,000 )
2020	2020	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	6	6/5/2020	COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2019 ( Subtotal = $25,000 )
2019	2019	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	5	6/24/2019	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2018 ( Subtotal = $25,000 )
2018	2018	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	4	6/6/2018	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2017 ( Subtotal = $25,000 )
2017	2017	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	3	6/16/2017	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2016 ( Subtotal = $25,000 )
2016	2016	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	2	6/24/2016	NON-COMPETING CONTINUATION	$25,000
														Subtotal = $25,000

Issue Date FY: 2015 ( Subtotal = $25,000 )
2015	2015	NORTHEASTERN UNIVERSITY	360 HUNTINGTON AVENUE	BOSTON	MA	02115	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	1	7/7/2015	NEW	$25,000
														Subtotal = $25,000

Grand Total All Awards = $250,000

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Chemistry and Pharmacology of Drugs of Abuse Annual Symposium

Award Number: R13DA040423

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 07/15/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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