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AACR Special Conference on Evolutionary Dynamics in Carcinogenesis and Response to Therapy

Award Number: R13CA243226
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2020
PERIOD OF PERFORMANCE END DATE: 08/27/2020

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AACR Special Conference on Evolutionary Dynamics in Carcinogenesis and Response to Therapy - PROJECT SUMMARY The proposed conference, titled “Evolutionary Dynamics in Carcinogenesis and Response to Therapy,” will be held March 12-15, 2020 in Denver, Colorado. Two of the most critical issues in current cancer research are 1) defining the biological basis for the vast intratumoral heterogeneity observed in patients and 2) understanding the underlying processes in therapy resistance. Both issues stem from Darwinian evolutionary dynamics wherein selection forces are imposed on a population with heritable variability. In the instance of cancers, the interactions of individual cancer cells with one another, the surrounding tissues, and the immune system govern the evolution of cancers from carcinogenesis through treatment response (1-2). The concept of cancer as an evolutionarily guided process has been recognized for over forty years (14) but has focused mainly on the genetic diversity of cancers. The aim for this conference is to move away from the simplistic view of cancer evolution as a merely genetic phenomenon and to discuss instead how microenvironmental, immune cell, genetic, and epigenetic heterogeneity interact and how this influences cancer progression and therapy success or failure. Moreover, this conference will meet the need for practical application of evolutionary theory by providing a venue to synthesize concepts in evolutionary dynamics from basic cancer research into clinical applications. There is currently a dearth of opportunities in the United States for investigators to meet and share research on this subject. The program has been carefully designed to feature thought-provoking sessions on clonal evolution, generation of genomic and epigenomic diversity, mechanisms of dynamics and resistance, longitudinal dissection of resistance evolution, and evolutionary guided therapy. Attendance will help better disseminate the rapidly growing collection of research innovations. Collaboration and networking will also be encouraged by incorporating multiple opportunities for thoughtful discussion and meaningful interaction between participants.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2021 ( Subtotal = -$2,500 )
2021	2020	AMERICAN ASSN FOR CANCER RES	615 CHESTNUT ST FL 17	PHILADELPHIA	PA	19106	PHILADELPHIA	USA	Cancer Biology Research	001	1	12/3/2020	NEW	-$1
2021	2020	AMERICAN ASSN FOR CANCER RES	615 CHESTNUT ST FL 17	PHILADELPHIA	PA	19106	PHILADELPHIA	USA	Cancer Biology Research	000	1	11/6/2020	NEW	-$2,499
														Subtotal = -$2,500

Issue Date FY: 2020 ( Subtotal = $2,500 )
2020	2020	AMERICAN ASSN FOR CANCER RES	615 CHESTNUT ST FL 17	PHILADELPHIA	PA	19106	PHILADELPHIA	USA	Cancer Biology Research	000	1	2/28/2020	NEW	$2,500
														Subtotal = $2,500

Grand Total All Awards = $0

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AACR Special Conference on Evolutionary Dynamics in Carcinogenesis and Response to Therapy

Award Number: R13CA243226

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2020

PERIOD OF PERFORMANCE END DATE: 08/27/2020

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