2025 Epithelial Differentiation and Keratinization Gordon Research Conference and Gordon Research Seminar - Project Summary The 2025 Gordon Research Conference on Epithelial Differentiation and Keratinization (GRC-EDK) is the leading international meeting in the field of epithelial biology. Since its inception in 1979, the biennial GRC-EDK has contributed to scientific advances and shaped therapeutic approaches for treating skin conditions. For over four decades, the GRC-EDK has had a high level of attendance, the consistent participation of world-renowned experts in the field, and highly favorable reviews from conference attendees. The 2025 GRC-EDK conference is entitled Epithelial Development, Aging, Disease, and Regeneration Across Cells and Systems and will take place in Ventura Beach, California, from June 1-6, 2025. The 2025 GRC-EDK will celebrate its 46th year, continuing its tradition of addressing cutting-edge basic questions in epithelial biology and ways of translating these discoveries into disease treatment. It will showcase recent conceptual and technological advances comprising stem cell biology, regenerative medicine, cancer, immunity, aging, epigenetics, skin diseases, novel single-cell and spatial transcriptomics technologies, and global genomics. GRC-EDK also acts as a platform to support the careers of a full range of investigators, including women and men, young investigators, and investigators from different cultural and ethnic backgrounds. More than 15% of the invited speakers are from fields beyond the immediate scope of the conference, 85% did not present at the previous meeting, and over 30% of speakers will be selected from abstract submissions to ensure plentiful opportunities for junior faculty and trainees. The relatively secluded location for the 2025 GRC-EDK and the allocated informal afternoon periods are chosen to maximize the potential for in-depth scientific discussions, mentoring, and the initiation of collaborations among conference participants. The power hour is an important part of the GRC-EDK meeting and will encourage discussions on overcoming discrimination and facilitating diversity and inclusion in the scientific community. The commitment to nurturing the next generation of scientists will continue with the 6th Gordon Research Seminar on Epithelial Differentiation and Keratinization (GRS-EDK), scheduled at the same location and just before the main conference from May 31-June 1, 2025. This seminar is organized by and for trainees and offers a supportive environment for presenting research, networking, and fostering collaborations. A career mentoring panel at the GRS-EDK will address key topics such as career development, choices between academia and industry, and the critical importance of diversity in science. Taken together, the 2025 GRC/GRS-EDK exemplifies the NIAMS institute's strategy with the following main objectives: (i) to advance pioneering research in skin biology, (ii) to facilitate the transition of scientific discoveries to clinical practice, and (iii) to support the professional development of early-career scientists and trainees to sustain innovation in the field.
