Sunday, June 1, 2025
6/1/2025
CSHL 2025 Systems Immunology Conference - Cold Spring Harbor Conference on Systems Immunology Cold Spring Harbor, NY April 22 – April 26, 2025 ABSTRACT Immune responses are prosecuted by diverse cells and molecules operating in different spatial contexts within tissues and organs, across different scales, and over time. For example, highly diverse repertoires of lymphocyte receptors can discriminate between self and non-self antigens, triggering dynamic cell-cell interactions with both immune and non-immune cells, enabling the delivery of tightly targeted effector functions, including antibody production and killing of virus-infected cells. Over the past century, critical discoveries have been made by experimental immunologists studying individual molecules, cells, and their interactions, increasingly enabled by the application of new technologies. These data have revealed a complexity of interactions among diverse immune components, but many fundamental issues of how such complexity is orchestrated and regulated at scale, across whole organisms remain unresolved. Further progress requires an integration of high-dimensional multi-omic approaches, and computational and quantitative modeling to interrogate cellular behaviors at the various scales of the system. These properties cannot be analyzed or intuited by conventional experiments. It is clear that effective collaborations between experimental immunologists and computational and systems biologists are required to advance our systems-level understanding of immune responses. This meeting is the fourth in a biennial series aimed at catalyzing a cross-disciplinary exchange of new ideas, technologies, and analysis methodologies in the rapidly evolving and expanding field of systems immunology. Building on the successes of our previous meetings held at CSHL in 2019, 2021, and 2023, we have established this recurring meeting as the leading forum that can sustain a highly interactive community of Systems Immunologists. The proposed meeting will focus on recent advances at the interface of immunology and systems and computational biology, including rational design and applications of engineered immune particles and cells. Sessions will highlight multi-dimensional experimental platforms, the latest approaches to understand the spatial context of immune responses, and computational methods that are being used to analyze signaling and genomic cell states that control discrete effector responses in space and time. Integration of immunogenic, tolerogenic or pathophysiologic responses at different levels of scale – cellular, tissues and organs in mice and humans will be explored. Shared and unique design principles that underlie the development, functioning and evolution of the immune system will be discussed from an analytic standpoint. Throughout the sessions, we will showcase current efforts to apply systems biology methodology to human immunology and tissue immunity, including high- dimensional analyses of longitudinal samples obtained from experimental medicine studies in autoimmunity and infection. The meeting will nurture and foster a community of systems immunologists that are coupling high- dimensional profiling and imaging with computational and quantitative analyses to deepen the understanding of immune system states and responses. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include primarily graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. We will also host “meet the speaker” lunch sessions, providing a specific opportunity for students to interact with distinguished immunologists in the field. The meeting will be of moderate size and we expect about 250-300 people to participate in person, the ma
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