Tuesday, April 29, 2025
4/29/2025
2025 RNA Editing Gordon Research Conference and Gordon Research Seminar - Project Summary The GRC on RNA Editing is the most important international meeting addressing the modifications that alter the 4 standard nucleosides found within RNA and their implications in health and disease. Today, we realize that RNA editing and modifications play fundamental roles in translation, gene expression, innate and adaptive immunity, cognition, neurological disorders, cell differentiation, and cancer. Furthermore, population-wide human genome data has associated polymorphisms in modification enzymes, and their RNA targets, with varied disorders, providing crucial genetic links. Importantly, paths have been forged between basic science and industry by repurposing RNA editing and modification systems as therapeutics. In these efforts, investigators associated with the GRC are paving the way by founding a series of biotechnology companies based wholly or partly on these technologies. Accordingly, the GRC on RNA Editing is an impactful event where international leaders in the field meet with promising early career principal investigators and trainees to share data and ideas in order to nucleate the next generation of consequential discoveries. To support these overarching goals, the 2025 GRC on RNA Editing will focus on the following specific aims. First, this event will help develop the next generation of scientific leaders that will drive the field of RNA editing and modifications forward. To support this aim, the GRC will be preceded by a 2-day GRS, focused entirely on trainees and their mentorship. Moreover, the RNA Editing GRC will strategically ensure that our community is diverse, equitable and inclusive by supporting trainees and early career scientists, women, and underrepresented scientists, and by offering a “power hour” focused on promoting diversity and inclusion and career development. Second, the meeting will stimulate the exchange of transformative ideas in the area of RNA editing and modifications in order to nucleate novel, interdisciplinary discoveries. This aim is facilitated by the unique GRC format which, besides the talks, sponsors forums, and provides generous free time to promote networking. During the 5-day GRC itself, 51 talks and 2 keynote addresses will be spread out over 9 thematically diverse sessions with strong ties to many human diseases. Third, this GRC will facilitate the translation of academic discoveries in the area of RNA editing and modification into health-related industrial applications. Towards this aim, we will include many representatives from RNA editing and modifications companies, who will give talks and participate in mentorship sessions. One entire session will be dedicated to novel therapeutic applications of RNA editing systems. In conclusion, the 2025 GRC on RNA Editing will accelerate discovery and application of RNA editing and modification by inspiring research into biological mechanisms, by fostering knowledge translation, by building a strong, diverse, and inclusive community and by developing the next generation of creative scientists. Thereby, it will ultimately promote broad research initiatives, biotechnological and economical advancements, and improvements to human health.
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