Fibrosis: Inflammation, Drivers, and Therapeutic Resolution - ABSTRACT Support is requested for a Keystone Symposia conference entitled Fibrosis: Inflammation, Drivers, and Therapeutic Resolution, organized by Drs. Valerie Horsley, Michael Longaker and Thomas Wynn. The conference will be held in Whistler, BC, Canada from December 8-12, 2024. Fibrosis is characterized by aberrant fibroblast activation and inadequate tissue repair. Fibrosis is a common end-stage pathology in all major internal organs and solid tumors causing 45% of deaths in Europe and North America. While advances have been made in the understanding of molecular mechanisms driving tissue injury and fibrosis, there remains a need to identify targets/pathways that are relevant to human disease and can be leveraged to promote repair and regeneration, as well as to develop translational strategies to facilitate clinical development of novel therapies. This long-standing symposium series will serve as an engaging platform for world-renowned researchers across the globe, both early-career and established, to exchange ideas, showcase pioneering findings, and foster fruitful collaborations on topics of clinical innovations, immunobiology, and mechanobiology in the field of fibrosis research. The program will include workshops on multiomics approaches and lessons learned across tissues, as well as poster sessions, and informal activities to facilitate community building and in-depth discussions. Additionally, the conference will provide unparalleled opportunities for mentoring, training, and interactive scientific exchanges. With its wide-ranging scope of topics and unique opportunities for cross-industry and multi-disciplinary collaborations spanning different organ systems, no other meeting in this area rivals the comprehensive platform offered by this Keystone Symposia conference.
