ABSTRACT
Support is requested for a Keystone Symposia conference entitled Transcription and RNA Regulation in
Inflammation and Immunity, organized by Drs. Silvia Monticelli, K. Mark Ansel, Sarah Teichmann and
Gioacchino Natoli. The conference will be held in Tahoe City, California from February 2-5, 2019.
The immune system is a heavily armed but carefully tuned defense mechanism that must mount protective
responses against invading pathogens, while at the same time avoiding excessive inflammation and
inappropriate responses that can lead to severe tissue damage and disease. Properly regulated immune
responses are the result of a complex interplay between chromatin modifications, transcription factors and
post-transcriptional regulators that operate collectively within each cell to regulate the gene expression
programs that control immune cell differentiation, maintenance of cell identity, and the orchestration of
functional responses in a dynamic environment. Recent technical advances in genomics and single-cell
analyses have brought new ideas and perspectives to investigation of the regulation of gene expression, and
our understanding of the mechanisms and regulatory networks that operate in the immune system is
advancing at an unprecedented rate. This meeting will be important to define the most impactful questions and
future challenges in the field of transcriptional and post-transcriptional control of immune cells, and it will bring
together rapidly expanding and evolving communities. The exchange of scientific knowledge and technical
capabilities will foster opportunities for collaborations and interdisciplinary interactions among groups of
scientists working on disparate aspects of regulation of gene expression in inflammation and immunity,
highlighting the latest innovations and discoveries while shaping future directions for the field.