Friday, June 6, 2025
6/6/2025
2025 Biology of Aging Gordon Research Conference and Seminar - PROJECT SUMMARY This application requests funds to support the 2025 Gordon Research Conference (GRC) on the Biology of Aging, to be held at the Renaissance Tuscany Il Ciocco in Barga (Italy) on August 3 – 8, 2025, and the Gordon Research Seminar (GRS), which will be held at the same location on August 2 – 3, 2025, immediately prior to the GRC. This will be the seventeenth Biology of Aging meeting since its origin in 1962. This meeting is unique in its diversity, reflected in the theme of the 2025 conference: “Biology of Aging Across Scales: Molecular, Cellular, Organismal”. Over recent decades, the field has made remarkable progress in elucidating the key hallmarks of aging at increasingly refined molecular and cellular levels. These advances have fostered a paradigm shift in our understanding of aging, revealing it to be a malleable process amenable to intervention. This plasticity extends beyond cellular models and invertebrates, encompassing a wide range of vertebrates and even humans. At the same time, rapid technological innovations and the diversification of experimentally tractable model organisms have enabled researchers to examine aging from a more holistic perspective. We now have a far more nuanced portrait of aging, offering unprecedented insights into the intricate interplay between the immune system, the brain, the genome, and the aging process itself. This has also opened new avenues for potential therapeutic interventions across various biological scales. Biology of Aging GRC will highlight some of these emerging top-down approaches to understanding aging with a focus on reproductive aging, intertissue signaling, epi/genetics, and comparative biology. Our goal is to remain the premier forum for coalescing the field and fostering the discussion of concepts and presentation of unpublished research at the forefront of discovery related to systemic aging. Funds are requested to help cover expenses of invited speakers, meritorious junior scientists and minority trainees who will benefit from formal and informal interactions with senior scientists, to present their research findings, receive feedback from experts in the field, and exchange ideas for shaping the field. Invited speakers include established as well as outstanding early career scientists selected for the quality of their science and ability to stimulate debate. We will provide a forum for both formal and informal interactions between trainees and faculty at all stages to promote the exchange of ideas and collaborative synergies around reproductive aging. Poster and oral presentations will examine aging at the molecular, cellular and organismal level, including its molecular drivers, and the effects of genetic and environmental factors on relevant cellular/system properties, interactions, and interventions across diverse model systems ranging from worms to humans. This unique conference will bring together scientists tackling this problem from fundamental to clinical angles to brainstorm creative ways to build and strengthen the field.
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