Wednesday, April 30, 2025
4/30/2025
Transcription, Chromatin, and Epigenetics in Aging - SUMMARY The goal of this FASEB meeting “Transcription, Chromatin and Epigenetics in Aging” is to cover innovative topics in the roles epigenetic mechanisms play in the regulation of aging and how this is linked to disease states. In this meeting we will cover both fundamental mechanisms as well as novel therapeutic strategies for age-related diseases, introducing for the first time a metabolism session as well as three interdisciplinary and therapeutic- related sessions. Epigenetic mechanisms encompass post-translational modifications of chromatin and RNA as well as transcriptional regulation, which together define the transcriptional program of the cell. This FASEB meeting will be unique in integrating the latest discoveries in epigenetics and their importance in aging as well as ‘novel therapeutic strategies for age-related diseases. There is a vital need for such a meeting, particularly in bringing in together scientists at the forefront of both fields, to discuss interdisciplinary approaches to address key questions in both fields. Exciting recent studies have revealed how organismal and cellular aging can be regulated by epigenetic mechanisms, and how this is link to the metabolic state of the cell and its microenvironment. The field of epigenetic is rapidly expanding, and the aging field can benefit from the latest discoveries and advances in technologies in this area. Conversely, challenges and questions about the role of epigenetics in aging and age-related diseases abound, and it is critical for researchers in the chromatin and transcription fields to better grasp the implications of their work for health and disease. This FASEB meeting will discuss cutting-edge questions in field focusing on the key topic of the underlying molecular mechanisms that govern epigenetic regulation in aging. The meeting will cover new frontiers, including the exciting emerging field of RNA epigenomics and new interdisciplinary chemical-biology approaches to study these. The meeting will particularly focus on transformative epigenomic technologies including the development and utility of new chemical modalities to manipulate and eventually target these for therapeutics. This meeting will foster exciting interactions between scientists addressing fundamental questions, developing new methodologies and therapeutic modalities. The meeting will also provide a uniquely interactive, diverse, and inclusive forum throughout the meeting through short talks, poster teasers and sessions and promoting several networking and meet-the-expert events. To further enhance our support of the next generation of scientist, we established for the first time a full day of FASEB-Junior section that is dedicated to career-development and networking for trainees and new investigators. Bringing these young investigators at early stages of their career will not only encourage them to work in this field but also foster long-term interdisciplinary collaborations in very different areas that will be highly beneficial for both fields.
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