PROJECT SUMMARY / ABSTRACT
The funds requested in this R13 application are for partial support of “Systems Biology of Aging: Data-science
meets Gero-science” annual meetings to be offered each August/September from 2019 through 2022 at The
Jackson Laboratory for Genomic Medicine (JAX-GM) in Farmington, Connecticut. This meeting will bring
together up to 150 interdisciplinary scientists including molecular biologists, immunologists, computational
biologists, and geriatricians, who share a common interest in understanding aging and aging-associated disease
at the systems level. Many aging-associated diseases, such as cancer and cardiovascular disease, are
influenced by dysfunctions in the immune system. Recent advances in genomic profiling techniques (e.g., single
cell transcriptomics) provide an opportunity to uncover aging-related changes in human cells/tissues and to link
these changes to health and lifespan. The wealth and complexity of data produced using these technologies is
ever increasing, as is the need to develop advanced computational methods to mine and integrate these data.
Despite this need, there are currently no formal venues at which scientists, specifically those in the aging field,
can be trained in the basics and application of data mining techniques (i.e., machine learning
algorithms). Furthermore, current conferences on aging are not aimed at specifically bringing together
computational biologists, immunologists and basic and clinical aging researchers. Therefore, the objectives of
this meeting are: (1) to recognize and emphasize the highly interdisciplinary nature of the aging field and to
promote and accelerate collaborations and cross-pollination of ideas across the three disciplines: aging,
immunology, and computational biology; (2) to provide trainees (students and postdoctoral fellows) an
opportunity to closely interact with, and gain feedback from, more senior investigators to advance their projects
and establish connections to help build their careers; and (3) to provide an opportunity for researchers in the
field of aging to learn the basics of machine learning techniques, which they will be able to immediately apply to
their own research upon return to their home institutions. We will reach these objectives through carrying out the
following Aims. In Aim 1, we will organize an interdisciplinary meeting and hands-on workshop focused on aging
and aging-related diseases. The meeting will include a 2-day seminar session featuring talks by leading
scientists, followed by a 1-day hands-on workshop on the basics of machine learning. In Aim 2, we will promote
interactions to foster collaborative research and career advancement, including through a poster session. In Aim
3, we will recruit diverse attendees. Our proposed speaker list features several female scientists, and we will use
our partnership networks to specifically recruit attendees from nationally underrepresented racial and ethnic
groups. The ultimate goal of the meeting is to advance the aging research field through expediting collaborations
and the understanding of aging-related genomic data via application of advanced data mining approaches.