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TSSK-dependent signaling pathway in spermatogenesis

Award Number: R03TR003626
ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/01/2022
PERIOD OF PERFORMANCE END DATE: 11/30/2023

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TSSK-dependent signaling pathway in spermatogenesis - ABSTRACT Testis-specific serine kinases (TSSKs) belong to AMPK-related kinase family. Loss-of-function mutants of some TSSK members lead to spermatogenesis defects in male mice, and several SNPs of TSSKs are associated with male infertility in humans. However, the TSSK signaling mechanism during spermatogenesis is not understood. This proposal employs Drosophila as a model system to investigate a novel kinase-substrate pair: TSSKs-class IIa HDACs. Aim 1 will determine whether class IIa HDACs are substrates of TSSKs using both biochemical and genetic approaches. Aim 2 will explore the functional relevance of TSSKs-class IIa HDACs during spermatogenesis in Drosophila. Collectively, this proposal will establish class IIa HDACs as the key downstream component of TSSK signaling.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Trans-NIH Research Support	000	1	4/16/2024	NEW	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $161,500 )
2022	2022	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Trans-NIH Research Support	000	1	5/11/2022	NEW	$161,500
														Subtotal = $161,500

Grand Total All Awards = $161,500

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TSSK-dependent signaling pathway in spermatogenesis

Award Number: R03TR003626

ORGANIZATION: NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/01/2022

PERIOD OF PERFORMANCE END DATE: 11/30/2023

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