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Neural mechanism of critical self-judgment as a trans-diagnostic therapeutic target: a secondary data analysis study from the RDoC perspective

Award Number: R03MH136402
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2024
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Neural mechanism of critical self-judgment as a trans-diagnostic therapeutic target: a secondary data analysis study from the RDoC perspective - Project Summary Critical self-judgment is a common phenomenon underlying a wide range of psychological disorders. The proposed project aims to investigate the neural mechanism of critical self-judgment by analyzing fMRI and questionnaire data from a total of 203 subjects collected from 5 previous projects that all included mindfulness or compassion-based interventions for various conditions, e.g., depression, anxiety, trauma, stress and chronic pain. The analyses will particularly evaluate the effective and functional connectivity among the amygdala, the hippocampus, inferior frontal gyrus and precuneus, to test the central hypothesis that critical self-judgment is characterized by excessive influence from negative valence on the left Inferior Frontal Gyrus-Pars Triangularis (IFGPT), a key area for internal speech and self-awareness, which further influences the precuneus (PCu) of the default mode network (DMN), a neural circuitry that supports self-referential processes. Aim 1: To elucidate the effective connectivity in the neural circuitry during critical self-judgment. Using fMRI data from a self-reappraisal task that included self-critical vs. self-reassurance conditions, Granger Causality analysis will be conducted with fMRI time series from regions of interest of the hypothesized neural circuitry to test whether there is significant effective connectivity in the directions of amygdala→IFGPT and IFGPT→PCu during self-critical condition. Similar analyses with the self-reassurance condition will test whether there is significant effective connectivity in the direction of MPFC→amygdala and IFGPT→amygdala, reflecting frontal inhibition of negative affect. Aim 2: To identify features from resting state fMRI that are associated with trait critical self-judgment. Through analyzing resting state fMRI data with the CONN toolbox, we will extract Resting State Functional Connectivity (RSFC) from regions of interest in the proposed neural circuitry, then use linear mixed effects models to test whether the severity of trait critical self-judgment is collectively predicted by RSFC of hippocampus-IFGPT, amygdala-IFGPT, IFGPT-PCu, hippocampus-PCu and amygdala-PCu. Aim 3: To investigate whether post-intervention changes in trait critical self-judgment are predicted by changes in the proposed neural circuitry. By analyzing post-intervention changes in fMRI metrics and trait critical self-judgment severity, we will test whether post-intervention changes in trait critical self-judgment are predicted by post-intervention changes in RSFC of hippocampal-IFGPT, amygdala-IFGPT, IFGPT-PCu, hippocampus-PCu and amygdala-PCu.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1 )
2026	2025	CAMBRIDGE PUBLIC HEALTH COMMISSION	1493 CAMBRIDGE ST	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Mental Health Research Grants	000	2	6/8/2026	NON-COMPETING CONTINUATION	-$1
														Subtotal = -$1

Issue Date FY: 2025 ( Subtotal = $82,000 )
2025	2025	CAMBRIDGE PUBLIC HEALTH COMMISSION	1493 CAMBRIDGE ST	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Mental Health Research Grants	001	2	9/23/2025	NON-COMPETING CONTINUATION	$12,300
2025	2025	CAMBRIDGE PUBLIC HEALTH COMMISSION	1493 CAMBRIDGE ST	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Mental Health Research Grants	000	2	2/19/2025	NON-COMPETING CONTINUATION	$69,700
														Subtotal = $82,000

Issue Date FY: 2024 ( Subtotal = $82,000 )
2024	2024	CAMBRIDGE PUBLIC HEALTH COMMISSION	1493 CAMBRIDGE ST	CAMBRIDGE	MA	02139	MIDDLESEX	USA	Mental Health Research Grants	000	1	3/1/2024	NEW	$82,000
														Subtotal = $82,000

Grand Total All Awards = $163,999

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Neural mechanism of critical self-judgment as a trans-diagnostic therapeutic target: a secondary data analysis study from the RDoC perspective

Award Number: R03MH136402

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2024

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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