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Secondary Histologic Analysis of TUS Studies

Award Number: R03MH135445
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2024
PERIOD OF PERFORMANCE END DATE: 12/31/2025

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Secondary Histologic Analysis of TUS Studies - Project Abstract The nucleus accumbens (NAc) is a target for non-invasive brain stimulation for the treatment of substance use disorders (SUDs). Due to its location deep in the brain, transcranial ultrasound stimulation (TUS) is unique among non-invasive brain stimulation methods to be able to focus on the NAc with high spatial resolution. TUS has been shown to be effective in animal models, without any evidence of damage from either behavioral studies, H&E stained sections, or TUNEL staining. Further, there have been millions of diagnostic imaging studies at the pressures proposed for TUS, that have appeared to be safe. As a result, it is currently under active investigation in humans. However, when it comes to safety, we are compelled to examine all existing data. In particular, we have existing data from our prior studies in which we applied TUS to the sheep brain and examined it on H&E stained sections, as well as TUNEL staining. Here in this proposal, we seek to extend this analysis to the examination of inflammatory cytokines and the examination of glial cells using immunohistochemistry. These studies will give us a more complete picture whether TUS has an inflammatory effect on the brain.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $77,200 )
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	2	12/19/2024	NON-COMPETING CONTINUATION	$65,620
2025	2025	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	001	2	9/22/2025	NON-COMPETING CONTINUATION	$11,580
														Subtotal = $77,200

Issue Date FY: 2024 ( Subtotal = $77,200 )
2024	2024	THE LELAND STANFORD JUNIOR UNIVERSITY	450 JANE STANFORD WAY	STANFORD	CA	94305	SANTA CLARA	USA	Mental Health Research Grants	000	1	1/1/2024	NEW	$77,200
														Subtotal = $77,200

Grand Total All Awards = $154,400

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Secondary Histologic Analysis of TUS Studies

Award Number: R03MH135445

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2024

PERIOD OF PERFORMANCE END DATE: 12/31/2025

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