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Understanding the role of the frontal cortex during cognitive flexibility in Fmr1 knock outs

Award Number: R03MH133173
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 03/01/2023
PERIOD OF PERFORMANCE END DATE: 02/28/2026

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Understanding the role of the frontal cortex during cognitive flexibility in Fmr1 knock outs - PROJECT SUMMARY Autism spectrum disorder (ASD) is a neurodevelopmental disorder where individuals exhibit deficits in cognitive flexibility. Purpose: This proposal will record from the frontal cortex of Fmr1 KOs (model of Fragile X syndrome) during cognitive flexibility tasks and assess how neural hyperexcitability within the KOs impacts reversal learning and shifts of attention. Methods: Fmr1 KOs and wildtype rats will be trained on categorical perception tasks with touchscreens in operant chambers. Single-unit neurophysiology and local field potentials will be collected from the frontal cortex (including the anterior cingulate) during the tasks. It is important to understand how altered neural function within the KOs impacts cognitive function and learning. This project will compare neural activity from putative pyramidal and interneurons to examine differential functions during cognition. Examining these differences in neural function between KOs and WT will enhance our understanding of how cortical excitability impacts cognition. The local field potentials can provide templates of neural signatures that in future studies can be compared to electroencephalography data from humans with ASD or Fragile X.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $0 )
2026	2024	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	2	6/3/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $71,589 )
2024	2024	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	2	2/15/2024	NON-COMPETING CONTINUATION	$64,430
2024	2024	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	001	2	8/12/2024	NON-COMPETING CONTINUATION	$7,159
														Subtotal = $71,589

Issue Date FY: 2023 ( Subtotal = $71,819 )
2023	2023	KANSAS STATE UNIVERSITY	1601 VATTIER STREET	MANHATTAN	KS	66506	RILEY	USA	Mental Health Research Grants	000	1	2/24/2023	NEW	$71,819
														Subtotal = $71,819

Grand Total All Awards = $143,408

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Understanding the role of the frontal cortex during cognitive flexibility in Fmr1 knock outs

Award Number: R03MH133173

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 03/01/2023

PERIOD OF PERFORMANCE END DATE: 02/28/2026

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