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IDENTIFICATION OF INHIBITORS OF THE PLASMODIUM FALCIPARUM M18 METALLOPROTEASE

Award Number: R03MH084103
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 06/04/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2009

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IDENTIFICATION OF INHIBITORS OF THE PLASMODIUM FALCIPARUM M18 METALLOPROTEASE - DESCRIPTION (provided by applicant): Malaria remains a significant cause of morbidity and mortality worldwide with an estimated 2 million people dying from this disease every year. The majority are children under 5 living in Sub-Saharan Africa. Drug resistance to the commonly available drugs is widespread, and with a safe and effective vaccine still many years away, new chemotherapeutic agents are required to ensure that cheap and effective treatment can be maintained. The M18 class of metalloproteases are involved in the catabolism of proteins. In the apicomplexan parasite of the genus Plasmodium the causative agent of malaria, this key enzyme is involved with hemoglobin digestion. Using an antisense transgenic approach we have shown that it is possible to selectively target this enzyme. This leads to a lethal phenotype. We have generated a recombinant protein to this enzyme that is suitable for adaptation to high throughput screening. This will lead to the identification of new and novel compounds that can target this enzyme. Public Health Relevance: This Public Health Relevance is not available.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2008 ( Subtotal = $24,300 )
2008	2008	QUEENSLAND INSTITUTE OF MEDICAL RESEARCH	BRAMSTON TERRACE HERSTON	BRISBANE				AUS	Trans-NIH Research Support	000	1	6/4/2008	NEW	$24,300
														Subtotal = $24,300

Grand Total All Awards = $24,300

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IDENTIFICATION OF INHIBITORS OF THE PLASMODIUM FALCIPARUM M18 METALLOPROTEASE

Award Number: R03MH084103

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 06/04/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2009

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