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Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Improve Cardiovascular Function Among Adults with Type 1 Diabetes

Award Number: R03HL183276
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/15/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2028

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Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Improve Cardiovascular Function Among Adults with Type 1 Diabetes - PROJECT SUMMARY 8.4 million people with type 1 diabetes (PwT1D) have a 9- to 43-year shortened life expectancy and a ten- fold higher cardiovascular disease risk compared to the general population. Cardiovascular disease is the leading cause of death in PwT1D. Systolic blood pressure (SBP; pressure exerted on the walls of the arteries by blood when the heart is beating) is a leading modifiable risk factor for cardiovascular disease in PwT1D. Even young PwT1D have vascular dysfunction and an increased risk for adverse cardiovascular events and mortality. Therefore, identifying promising interventions to lower SBP and improve vascular function among young PwT1D is a critical biomedical research need. Three out of 5 adults with diabetes do not exercise enough, partly due to infrastructural barriers such as available facilities, equipment, and safe outdoor space. Further, aerobic exercise is difficult for PwT1D to adhere to because of low time availability and unique challenges for maintaining euglycemia (e.g., exercise-induced changes in glucose and insulin). Published data and our preliminary data demonstrate that high-resistance inspiratory muscle strength training (IMST) reduces SBP and improves vascular function in clinical populations. IMST has high adherence (>85%) in past studies and our ongoing K01-funded trial among adults with obesity, likely because IMST is home-based and takes just five minutes daily to perform a set of inhalations against resistance using a commercially available device (i.e., minimal equipment). However, the potential cardioprotective effects of IMST have not been examined in PwT1D. IMST is a novel, time-efficient, and low-risk (unlikely to induce hypoglycemia) strategy with a high promise to positively impact PwT1D. The physiological basis for IMST is strong for PwT1D as they are reported to have inspiratory muscle dysfunction and IMST specifically increases inspiratory muscle function. Therefore, our objective is to determine whether eight weeks of daily high-resistance IMST lowers SBP and improves vascular function among PwT1D using a randomized, parallel-arm, double-masked, sham-controlled pilot trial. We will also monitor respiratory function, adherence, safety, and tolerability. To this end, our specific aims are as follows: Aim 1: Determine whether eight weeks of IMST in PwT1D lowers SBP Hypotheses: IMST will decrease laboratory-measured causal and ambulatory 24-hour brachial SBP Aim 2: Determine whether eight weeks of IMST in PwT1D improves vascular function Hypotheses: IMST will increase brachial artery flow-mediated dilation and post-occlusion reactive hyperemia


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $218,937 )
2026	2026	FLORIDA STATE UNIVERSITY	874 TRADITIONS WAY	TALLAHASSEE	FL	32306	LEON	USA	Cardiovascular Diseases Research	000	1	8/7/2026	NEW	$218,937
														Subtotal = $218,937

Grand Total All Awards = $218,937

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Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Improve Cardiovascular Function Among Adults with Type 1 Diabetes

Award Number: R03HL183276

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/15/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2028

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