Friday, November 22, 2024 11/22/2024

The neurodevelopmental trajectory of reading: a publicly available multimodal neuroimaging database

Award Number: R03HD103862
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary (30 lines of text) Reading disability (RD) is the most common neurodevelopmental disorder of childhood, estimated to affect 10- 15% of children of otherwise typically developing children. RD is a life-long disorder with significant difficulties persisting into adolescence and adulthood in several domains. Understanding the key environmental, cognitive and neurobiological bases of reading and disorders is fundamental to improve diagnostics and treatment of reading disabilities. Although much progress has been made on how the neural circuitry for reading depends on reading ability, quantitative analyses of how the brain structure and function underlies reading as a function of age and ability, and their interaction, are still lacking. A number of relevant findings originated from our lab and were supported by a series of NICHD grants. Although we have made significant progress on each of these grants in isolation, we strongly believe that making these datasets available to the scientific community allows for addressing questions that so far remained unanswered and this constitutes the key significance of this proposal. Across studies we used comparable measures at the level of brain and behavior, and given the rich range on age, ability and comorbidity status and the comparability of measures the potential scientific yield from combining these data sets into a unified database is strong. Important neurodevelopmental questions about how component processing in reading changes with experience and their associated brain pathways and how this differs in good and poor readers will be addressable. Moreover, an important longer-term strategic plan for which this project would be a foundation is to involve our collaborators from the U.S and other countries in building upon and extending this database to address reading development across orthographies. The proposed database contains environmental and background data, structural and functional (print/speech localizer tasks) brain measures across age and sensitive cognitive measures of code utilization in word reading, and many other language related measures, that will allow the user to chart key brain/behavior relations. We have collected over 1000 neuroimaging scans from 700 individuals across the age range from 5-30 years old, from preliterate to highly proficient readers. All data will be fully anonymized, stored in the industry standard Brain Imaging Data Structure (BIDS) and uploaded, ultimately within a year after the grant's completion, on OpenNEURO. OpenNEURO is a free and open platform, approved by the NIH brain initiative (https://braininitiative.nih.gov/), for sharing in-vivo neuroimaging data. To increase awareness of the existence of this database, a white paper describing the richness and power of the data will be submitted after all data is uploaded. Additionally, we will inform other reading researcher using existing social media channels (e.g. Haskins twitter feed) and mail channels of conference attendees and other google mail lists.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	3	6/21/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $2,315 )
2023	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	002	2	9/13/2023	NON-COMPETING CONTINUATION	-$23,435
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	3	6/26/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$20,298
2023	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	2	6/26/2023	NON-COMPETING CONTINUATION	-$17,983
2023	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	003	3	9/13/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$23,435
														Subtotal = $2,315

Issue Date FY: 2022 ( Subtotal = $79,900 )
2022	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	2	2/24/2022	NON-COMPETING CONTINUATION	$71,910
2022	2022	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	2	5/27/2022	NON-COMPETING CONTINUATION	$7,990
														Subtotal = $79,900

Issue Date FY: 2021 ( Subtotal = $79,900 )
2021	2021	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	000	1	3/5/2021	NEW	$77,050
2021	2021	HASKINS LABORATORIES, INC.	300 GEORGE ST STE 900	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Child Health and Human Development Extramural Research	001	1	4/3/2021	NEW	$2,850
														Subtotal = $79,900

Grand Total All Awards = $162,115

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The neurodevelopmental trajectory of reading: a publicly available multimodal neuroimaging database

Award Number: R03HD103862

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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