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Establishing Cognitive-Motor Function as a Missing Therapeutic Target after Anterior Cruciate Ligament Reconstruction

Award Number: R03HD101093
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Establishing Cognitive-Motor Function as a Missing Therapeutic Target after Anterior Cruciate Ligament Reconstruction - The spectrum of cognitive-motor impairments following anterior cruciate ligament reconstruction (ACLR) is poorly defined. This knowledge gap is an important problem because recent evidence indicates that the current dependence on isolated motor tests for ACLR clinical decision making is insufficient to ensure restored function in complex sports environments or prevent a second injury. Under existing tests, the interaction between cognition and motor control is routinely missed and deficits are allowed to remain despite passing discharge criteria. Mounting evidence demonstrates that the interaction of cognitive and motor function is impaired after musculoskeletal injury, including ACL tears. There is a critical need for studies that establish the scope and severity of cognitive-motor impairments in ACLR patients to provide novel therapeutic targets. The long-term goal of this research is to improve ACLR rehabilitation outcomes. The objective of this R03 is to demonstrate the spectrum of cognitive-motor impairments with rigorous lab-based metrics following ACLR. Clinical translation will be achieved by validating cost-effective and simple tests for cognitive-motor performance against lab-based measures. The central hypotheses are that 1) simultaneous cognitive tasks will reveal neuromuscular impairments following ACLR, 2) clinical surrogate tests will be related to lab-based metrics, and 3) worse cognitive-motor impairments will predict poorer patient-reported outcomes of knee function and psychological factors. The study objective will be achieved through two specific aims: 1) elucidate the spectrum of dual-task impairments that persist following ACLR, and 2) demonstrate the clinical relevance of dual-task impairments following ACLR. For the first aim, 3D biomechanical analyses will be done for jumping tasks with an innovative approach of systematically adding simultaneous cognitive tasks (i.e., dual tasks) that target specific cognitive processes (e.g., decision making). Clinical cognitive-motor dual-task tests will also be validated. Greater increases in frontal plane knee motion (ACL injury risk factor) when visually- demanding cognitive tasks are added will support the primary hypothesis for the first aim. Strong correlations between dual-task impairments in clinic-based tests and dual-task impairments in frontal plane knee motion from lab-based tests will support the second hypothesis. Greater dual-task impairments on lab-based tests associating with worse patient-reported outcomes of knee function and psychological factors will support the hypothesis of the second aim. The approach is innovative because it will systematically introduce different types of cognitive challenges designed around the neurophysiological changes associated with ACL injury that go unquantified in current treatment. The research is significant because it will identify novel therapeutic targets for ACLR rehabilitation by determining the most salient cognitive-motor impairments and their clinical relevance. Ultimately, such knowledge has the potential to inform rehabilitation and injury prevention strategies for ACL tears that will help reduce the growing problem of sports injuries in the U.S.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Child Health and Human Development Extramural Research	000	2	2/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Child Health and Human Development Extramural Research	000	2	10/27/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $143,213 )
2022	2022	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Child Health and Human Development Extramural Research	000	2	11/18/2021	NON-COMPETING CONTINUATION	$128,891
2022	2022	MONTANA STATE UNIVERSITY	216 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Child Health and Human Development Extramural Research	001	2	4/19/2022	NON-COMPETING CONTINUATION	$14,322
														Subtotal = $143,213

Issue Date FY: 2021 ( Subtotal = $148,744 )
2021	2021	MONTANA STATE UNIVERSITY, INC	211 MONTANA HALL	BOZEMAN	MT	59717	GALLATIN	USA	Child Health and Human Development Extramural Research	000	1	11/11/2020	NEW	$148,744
														Subtotal = $148,744

Grand Total All Awards = $291,957

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Establishing Cognitive-Motor Function as a Missing Therapeutic Target after Anterior Cruciate Ligament Reconstruction

Award Number: R03HD101093

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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