Monday, November 25, 2024 11/25/2024

The molecular basis for the beneficial and deleterious functions of human MLH1-MLH3 complex

Award Number: R03HD098293
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Group Awards By:

View Award Abstract

Project summary: Homologous recombination that takes place in prophase of meiosis I is required for reproduction in humans and other eukaryotes. Defects in meiotic homologous recombination in humans cause infertility, miscarriages, and Down and Turner syndromes. The human MLH1-MLH3 complex (MutLγ) has been implicated in meiotic homologous recombination, but its function in this process has not been defined. In addition to having a key function in meiotic homologous recombination human MutLγ has other functions that are poorly understood. One of these functions is required for triplet repeat DNA expansion, a process that causes several neurodegenerative diseases. A lack of information about the action of MutLγ in meiotic recombination and triplet repeat DNA expansion is a major gap in our understanding of these key biological processes. Our preliminary data support the hypothesis that human MutLγ functions as an ATP-dependent endonuclease in meiotic recombination and triplet repeat DNA expansion. The goal of this project is to investigate MutLγ and its potential interactors and establish functional assays for future studies of MutLγ and MutLγ-dependent mechanisms. In Aim 1, we will study endonuclease and ATPase activities of MutLγ in assays that will produce novel insights into the functions of MutLγ in meiotic homologous recombination and triplet repeat instability. In Aim 2, we will identify proteins that interact with human MutLγ. The results of the proposed research will advance our understanding of MutLγ and will permit new studies into the mechanisms of MutLγ-dependent meiotic recombination and triplet repeat DNA expansion.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2021	BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY	900 S NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Child Health and Human Development Extramural Research	000	2	10/19/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $73,750 )
2021	2021	SOUTHERN ILLINOIS UNIVERSITY	900 SOUTH NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Child Health and Human Development Extramural Research	001	2	2/5/2021	NON-COMPETING CONTINUATION	$7,375
2021	2021	SOUTHERN ILLINOIS UNIVERSITY	900 SOUTH NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Child Health and Human Development Extramural Research	000	2	12/21/2020	NON-COMPETING CONTINUATION	$66,375
														Subtotal = $73,750

Issue Date FY: 2020 ( Subtotal = $73,750 )
2020	2020	SOUTHERN ILLINOIS UNIVERSITY	900 SOUTH NORMAL AVE	CARBONDALE	IL	62901	JACKSON	USA	Child Health and Human Development Extramural Research	000	1	12/20/2019	NEW	$73,750
														Subtotal = $73,750

Grand Total All Awards = $147,500

Top

All Categories

About

Search

Reports

Data Submission

Award Information

The molecular basis for the beneficial and deleterious functions of human MLH1-MLH3 complex

Award Number: R03HD098293

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer