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Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases

Award Number: R03EB038659
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 04/14/2026
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases - Project Abstract Atherosclerosis, the leading cause of cardiovascular diseases, occurs with compositional and mechanical changes in arterial walls that narrow and stiffen the artery. These mechanical changes are a warning sign for vascular health and predictors of heart attacks and strokes. Specifically, arterial stiffness and viscoelasticity may be used as mechanical biomarkers. Current measurement methods often rely on imaging or catheterization techniques that provide incomplete information, are unsuitable for long-term monitoring, and are often limited to superficial arteries. The primary limitation is the inability to simultaneously measure local arterial pressure and arterial strain. Despite the potential to use mechanical changes of artery walls as biomarkers for vascular diseases, there is currently no technology to enable daily monitoring of mechanical biomarkers. To address current shortcomings, we propose an implantable, vascular stent-based sensing platform to monitor arterial stiffness and viscoelasticity. Notably, the proposed system adapts the design of conventional vascular stents, which are already implanted several million times per year, to offer monitoring of vascular health biomarkers. Soft strain and pressure sensors will be printed and integrated with a stent platform for wireless monitoring from arteries. Capacitive sensors will be optimized for high sensitivity and integration with the stent. The stent is laser machined to act as an inductor for wireless communication while providing mechanics identical to conventional stents. The integrated device is wirelessly interrogated via inductive coupling, allowing for a passive and battery-free implant. The sensor system will be compatible with conventional catheter implantation and replicate the performance of conventional stents, but with the added benefit of providing insights into the patient’s vascular health. Wireless connectivity will be tuned to enable high sample rates at communication distances representative of implantation in coronary arteries. The device will be applied to measure mechanical changes in an artery model. Silicone arterial models with tunable viscoelasticity will be designed and fabricated to mimic atherosclerotic and restenosis conditions. The device will enable wireless recordings of pressure-diameter curves and arterial viscoelastic parameters, which will provide a means to remotely estimate arterial wall composition and disease progression. The long- term objective of this project is to enable at-home, daily monitoring of mechanical biomarkers of vascular diseases to improve patient outcomes. Moreover, the proposed device is expected to enable future studies on mechanical biomarkers, arterial wall remodeling, and mechanical homeostasis, which will enhance the understanding of vascular disease progression and treatment design.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $143,201 )
2026	2026	LOUISIANA STATE UNIVERSITY	202 HIMES HALL	BATON ROUGE	LA	70803	EAST BATON ROUGE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	4/17/2026	NEW	$143,201
														Subtotal = $143,201

Grand Total All Awards = $143,201

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Stent-based sensor system for continuous monitoring of mechanical biomarkers during vascular diseases

Award Number: R03EB038659

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 04/14/2026

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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