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Cell-homing exosomes as a drug delivery carrier to overcome multiple drug resistance

Award Number: R03EB028572
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/13/2019
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Cell-homing exosomes as a drug delivery carrier to overcome multiple drug resistance - Abstract Multiple drug resistance (MDR) to chemotherapeutic drugs remains the major obstacle for the effective treatment of cancers. Efflux transporters, mainly responsible for MDR, pump drugs from the cancer cells for subsequent elimination and untargeted distribution. As a result, insufficient drug deposition in the cells leads to the failure of treatment. As functional and extracellular nanovesicles derived from cells, exosomes play an essential role in the cell-cell communication. Emerging results have indicated that endogenous exosomes offer significant advantages for the delivery of therapeutic agents over traditional nanocarriers with cell-homing selectivity and low immunogenicity. Our recent studies have now defined that exosomes derived from drug-resistant cells significantly increased drug response to parental cells. The data also demonstrate that the ability of exosomes to increase the cytotoxicity of delivered anticancer drugs to resistant cells may obtain from not only energy-driven endocytosis pathways but also specific surface proteins-mediated homing selectivity. In this project, we plan to (1) characterize exosomes secreted by drug-resistant cancer cells and (2) determine the mechanism of homing selectivity of the isolated exosomes to drug-resistant cancer cells. With the completion of above initiative research, we expect that exosomes especially overcome pharmacoresistance in autologous drug-resistant cancer cells. The study will also improve the understanding of cancer cell-secreted exosomes in the role of drug resistance. The outcome will discover bioengineered exosomes as delivery platforms and lead to exosome-based strategies to overcome drug resistance, the toughest and most challenging hurdle in cancer therapy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$1,346 )
2023	2020	HUSSON UNIVERSITY	1 COLLEGE CIR	BANGOR	ME	04401	PENOBSCOT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	2/10/2023	NON-COMPETING CONTINUATION	-$1,346
														Subtotal = -$1,346

Issue Date FY: 2020 ( Subtotal = $64,030 )
2020	2020	HUSSON UNIVERSITY	1 COLLEGE CIR	BANGOR	ME	04401	PENOBSCOT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	8/26/2020	NON-COMPETING CONTINUATION	$64,030
														Subtotal = $64,030

Issue Date FY: 2019 ( Subtotal = $63,622 )
2019	2019	HUSSON UNIVERSITY	1 COLLEGE CIR	BANGOR	ME	04401	PENOBSCOT	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	9/13/2019	NEW	$63,622
														Subtotal = $63,622

Grand Total All Awards = $126,306

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Cell-homing exosomes as a drug delivery carrier to overcome multiple drug resistance

Award Number: R03EB028572

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/13/2019

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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