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Identifying the Role of Oral Health in Heart Disease through Integration of GWAS-by-Subtraction Genomic-Structural Equation Modeling with the Method of Instrument Variables

Award Number: R03DE034043
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary Our proposed project will build upon previous research which has shown an association between oral health and systemic health, including the relationship between heart disease and periodontitis. We will benefit from recent methodological advances in computational genomics and be the first study to provide causal evidence about the postulated relationship between poor oral health and heart disease using nationally-representative, longitudinal data. Specifically, we will construct polygenic scores using a GWAS-by-subtraction genomic structural equation model that are suitable for use in instrumental variables estimation. To accomplish our Aims, we will use longitudinal files containing 11 years of data (2006-2016) from the Health and Retirement Study (HRS). This longitudinal database will provide over 22,000 older Americans producing a sufficiently large sample size to overcome prior analytical obstacles. Aim 1. Determine the strength of genetic risk factors for poor oral health. The working hypothesis is that individual genetic composition is a strong predictor of poor oral health. Aim 2. Determine the causal effect of poor oral health on the probability of heart disease (HD). The working hypothesis is that variation in oral health due to individual genetic composition can be used to identify the causal effect of poor oral health on HD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $331,999 )
2024	2024	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Oral Diseases and Disorders Research	000	1	8/7/2024	NEW	$331,999
2024	2024	LEHIGH UNIVERSITY	526 BRODHEAD AVE	BETHLEHEM	PA	18015	NORTHAMPTON	USA	Oral Diseases and Disorders Research	001	1	8/19/2024	NEW	$0
														Subtotal = $331,999

Grand Total All Awards = $331,999

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Identifying the Role of Oral Health in Heart Disease through Integration of GWAS-by-Subtraction Genomic-Structural Equation Modeling with the Method of Instrument Variables

Award Number: R03DE034043

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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