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Germline risk of oral and oropharyngeal cancers across diverse populations

Award Number: R03DE030257
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2024

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Germline risk of oral and oropharyngeal cancers across diverse populations - PROJECT SUMMARY/ABSTRACT There is striking geographical variation in head and neck cancer squamous cell carcinoma (HNSCC) incidence globally. Some of the highest incidence rates have been observed in Southern and Eastern Europe and South America. The continual high HNC burden in these regions necessitates strong collaborative networks to assess susceptibility loci across and within ancestral backgrounds. This application brings together leading international groups with large, well characterized study populations, to investigate the role of germline variation in oral cavity and pharynx cancer in the largest genome-wide association (GWA) study of HNC to date. Previous data from 6035 cases and 6585 controls will be combined with recently generated data, supported by NIDCR and the Center for Inherited Disease Research (CIDR), from 4 IARC multi-center studies and 7 studies from Canada, US, UK, South America and Iran. Genotyping data from a total of 11,378 cases and 12,335 controls are included in the proposed work. Additionally, human papillomavirus (HPV) status will be available for all 4,454 oropharynx cancer cases, allowing a powerful stratified analysis by this important risk factor. Finally, the diverse populations included here will allow for identification of trans-ethnic and population- specific germline susceptibility variants to characterize susceptibility to varying risk for HNC across populations. The proposed project will define the role of the genetic factors involved in risk of HNSCC in European, North American, South American and Middle Eastern populations which may result in earlier detection and improved prevention and treatment strategies for HNSCC globally.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2022	CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER	25 AVE TONY GARNIER	LYON 7TH				FRA	Oral Diseases and Disorders Research	000	2	2/6/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $108,394 )
2022	2022	CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER	150 COURS ALBERT THOMAS	LYON				FRA	Oral Diseases and Disorders Research	001	2	7/29/2022	NON-COMPETING CONTINUATION	$108,394
2022	2021	CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER	150 COURS ALBERT THOMAS	LYON				FRA	Oral Diseases and Disorders Research	000	1	1/14/2022	NEW	$0
														Subtotal = $108,394

Issue Date FY: 2021 ( Subtotal = $113,423 )
2021	2021	CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER	150 COURS ALBERT THOMAS	LYON				FRA	Oral Diseases and Disorders Research	000	1	7/23/2021	NEW	$113,423
														Subtotal = $113,423

Grand Total All Awards = $221,817

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Germline risk of oral and oropharyngeal cancers across diverse populations

Award Number: R03DE030257

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2024

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