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Characterizing the role of cellular differentiation in productive papillomavirus amplification

Award Number: R03DE030211
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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Project Summary/Abstract Human papillomavirus (HPV) infections are responsible for a staggering 5% of all cancers worldwide. In the developed world, these infections cause an increasing number of oropharyngeal cancers. An estimated third of all oropharyngeal squamous cell carcinomas (OPSCC) are caused by HPV infection. Sexual behavior is a potent risk factor for HPV(+)-OPSCC, suggesting that a better understanding of viral transmission is critical. The viral lifecycle, specifically genome amplification and virion production, is intricately linked with cellular differentiation. We will characterize cellular genes that regulate the productive stages of the viral lifecycle. We will use HPV16 positive tonsillar epithelium equivalents grown in three-dimensional (3D) organotypic raft culture to recapitulate the effects of cellular differentiation on the viral lifecycle. Using this model system, we will use high-throughput approaches to identify cellular genes that regulate the productive viral lifecycle. Specifically, we aim to 1) identify how the expression of specific human genes co-varies with distinct phases in the viral lifecycle; 2) use a genetic screening approach to characterize cellular genes that are required for late gene transcription. The details regulating the late, productive stage of the viral lifecycle are not understood. Understanding the interplay between viral and cellular genes regulating cellular differentiation will lead to an improved basic biological knowledge of the papillomavirus life cycle and towards the development of possible interventions for HPV infections and associated cancers.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $153,500 )
2022	2022	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Oral Diseases and Disorders Research	001	2	4/21/2022	NON-COMPETING CONTINUATION	$15,350
2022	2022	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Oral Diseases and Disorders Research	000	2	1/3/2022	NON-COMPETING CONTINUATION	$138,150
														Subtotal = $153,500

Issue Date FY: 2021 ( Subtotal = $153,500 )
2021	2021	UNIVERSITY OF ARIZONA	888 N EUCLID AVE RM 510	TUCSON	AZ	85719	PIMA	USA	Oral Diseases and Disorders Research	000	1	2/8/2021	NEW	$153,500
														Subtotal = $153,500

Grand Total All Awards = $307,000

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Characterizing the role of cellular differentiation in productive papillomavirus amplification

Award Number: R03DE030211

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

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