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Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studies

Award Number: R03DE028505
ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 05/01/2019
PERIOD OF PERFORMANCE END DATE: 04/30/2023

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Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studies - PROJECT SUMMARY Population trends in aging present public health challenges in countries such as the USA and UK. Consequently, age-related health conditions such as sarcopenia (loss of muscle mass) are becoming increasingly prevalent. Oral health problems also increase dramatically with age, particularly tooth loss, periodontal disease, dry mouth, denture-related problems and chewing difficulties. Poor oral health has been implicated as a risk factor for sarcopenia. However, the extent to which and what particular oral health markers contribute to an increased risk of sarcopenia is not well-established. Moreover, the pathways or mechanisms by which oral health might influence sarcopenia are poorly understood. Current research is mostly from studies that are cross-sectional or have limited measures of sarcopenia and oral health in older populations. Such studies are not able to establish the contribution of oral health markers to the development of sarcopenia. To address these scientific evidence gaps, we aim to utilise data from two unique well-characterised cohort studies in the UK and USA. Our overarching goal is to investigate the contribution of oral health to the development of sarcopenia, and to understand the mechanisms underlying this relationship. Our research objectives are to: 1) determine the extent to which markers of poor oral health (periodontal disease, tooth loss, dry mouth, denture problems, chewing difficulties) are associated with incidence of sarcopenia over a 6-year follow-up; 2) determine the role of dietary factors as potential mechanisms underlying the association of poor oral health with incidence of sarcopenia; and 3) determine the role of inflammation as mediators of the association of poor oral health with incidence of sarcopenia. These will be achieved through secondary data analyses of two large population-based longitudinal studies of older people in the UK and USA, which are uniquely-placed for these investigations. These studies have detailed data on oral health, dietary factors, inflammation, as well as sarcopenia over time. The British Regional Heart Study is the only such longitudinal study of older people in the UK. The study comprises participants from 24 towns across Britain, followed-up at age 71-92 years in 2012 and at 77- 98 years. The US Health, Aging and Body Composition Study offers complementary data in a population-based study of older people from Memphis and Pittsburgh followed-up from age 71-80 years. These investigations based, on novel conceptual hypotheses and cross-country comparisons in UK and US studies, will significantly advance our understanding of the role that oral health plays in an important geriatric condition such as sarcopenia. The goal of this research is to provide the scientific basis for better identification and management of oral health conditions in older people, and to identify targets for interventions to reduce sarcopenia. These efforts are ultimately aimed at better health of older people.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$708 )
2024	2020	UNIVERSITY OF NEWCASTLE UPON TYNE	NEWCASTLE UNIVERSITY, KING'S GATE	NEWCASTLE UPON TYNE				GBR	Oral Diseases and Disorders Research	000	2	2/13/2024	NON-COMPETING CONTINUATION	-$708
														Subtotal = -$708

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2020	NEWCASTLE UNIVERSITY	KINGSGATE	NEWCASTLE-UPON-TYNE	TYNE AND WEAR			GBR	Oral Diseases and Disorders Research	000	2	4/28/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $105,141 )
2020	2020	NEWCASTLE UNIVERSITY	KING'S GATE	NEWCASTLE-UPON-TYNE	TYNE & WEAR	NE1 7RU		GBR	Oral Diseases and Disorders Research	000	2	7/10/2020	NON-COMPETING CONTINUATION	$105,141
														Subtotal = $105,141

Issue Date FY: 2019 ( Subtotal = $107,923 )
2019	2019	NEWCASTLE UNIVERSITY	KING'S GATE	NEWCASTLE-UPON-TYNE	TYNE & WEAR	NE1 7RU		GBR	Oral Diseases and Disorders Research	000	1	4/17/2019	NEW	$107,923
														Subtotal = $107,923

Grand Total All Awards = $212,356

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Understanding the contribution of poor oral health to sarcopenia in older age and underlying mechanisms using UK and US cohort studies

Award Number: R03DE028505

ORGANIZATION: NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 05/01/2019

PERIOD OF PERFORMANCE END DATE: 04/30/2023

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