Saturday, July 19, 2025 7/19/2025

REGULATION OF MYOSIN-X

Award Number: R03DC009887
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 08/25/2011
PERIOD OF PERFORMANCE END DATE: 07/31/2014

Group Awards By:

View Award Description

REGULATION OF MYOSIN-X - DESCRIPTION (provided by applicant): Alterations in the cytoarchitecture of the organ of Corti (OC) cause hearing loss in humans. The regulation of the actin cytoskeleton in epithelial cells of the OC is one of the key elements to understanding the pathogenesis of deafness. But little is known about the mechanism of actin-cytoskeletal modeling especially in supporting cells rather than sensory cells. The unconventional myosin-X (myoX) is an actin-associated motor protein that localizes to supporting cells. The overall hypothesis is that myoX and its binding partners are important regulators of the cytoarchitecture in the OC. The Specific Aims are to: (1) Investigate the developmental expression profiles of myoX in the OC of developing rodents; (2) Investigate the role of the binding proteins in the regulation of dimerization of myoX; and (3) Investigate the role of myoX in regulation of actin dynamics in cultured OC. These goals, to be accomplished by a combination of biochemical and cell biological approaches, will provide new insights into the development of new therapies and prevention of hearing loss.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2013 ( Subtotal = $129,184 )
2013	2013	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	002	4	7/19/2013	NON-COMPETING CONTINUATION	$155,515
2013	2012	BOSTON UNIVERSITY	25 BUICK ST	BOSTON	MA	02215	SUFFOLK	USA	Research Related to Deafness and Communication Disorders	001	3	3/5/2013	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$109,679
2013	2012	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	2	2/28/2013	NON-COMPETING CONTINUATION	-$136,010
														Subtotal = $129,184

Issue Date FY: 2012 ( Subtotal = $203,000 )
2012	2012	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	2	7/20/2012	NON-COMPETING CONTINUATION	$203,000
														Subtotal = $203,000

Issue Date FY: 2011 ( Subtotal = $203,000 )
2011	2011	BOSTON BIOMEDICAL RESEARCH INSTITUTE	64 GROVE STREET	WATERTOWN	MA	02472	MIDDLESEX	USA	Research Related to Deafness and Communication Disorders	000	1	8/22/2011	NEW	$203,000
														Subtotal = $203,000

Grand Total All Awards = $535,184

Top

All Categories

About

Search

Reports

Data Submission

Award Information

REGULATION OF MYOSIN-X

Award Number: R03DC009887

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 08/25/2011

PERIOD OF PERFORMANCE END DATE: 07/31/2014

Federal Websites

Department of Health & Human Services

HHS Operating Divisions

HHS Staff Divisions

Download A Document Viewer